Oliver R T, Pillai A, Klouda P T, Lawler S D
Cancer. 1977 Jun;39(6):2337-41. doi: 10.1002/1097-0142(197706)39:6<2337::aid-cncr2820390603>3.0.co;2-x.
The concept that HLA-linked immune response genes may influence survival of patients with malignant disease has been investigated by performing HLA typing on a series of 150 patients with acute myelogenous leukemia. Patients with A1 and B8 and/or A2 and B12 survival longer than patients without either of these pairs of antigens in association. However, after correction of the statistical probability for the number of A and B locus combinations theoretically possible, these differences are not statistically significant. Clarification of this must await independent analysis of other series and more direct approaches to the study of immune response genes in man.
通过对150例急性髓性白血病患者进行HLA分型，研究了HLA连锁免疫反应基因可能影响恶性疾病患者生存的这一概念。携带A1和B8及/或A2和B12的患者比不携带这两对相关抗原的患者存活时间更长。然而，在对理论上可能的A和B位点组合数量的统计概率进行校正后，这些差异无统计学意义。对此的澄清必须等待对其他系列进行独立分析以及采用更直接的方法来研究人类免疫反应基因。
