硬皮病中B8/DR3频率增加及该单倍型与细胞免疫反应受损的关联。
Increased frequency of B8/DR3 in scleroderma and association of the haplotype with impaired cellular immune response.
作者信息
Kallenberg C G, Van der Voort-Beelen J M, D'Amaro J, The T H
出版信息
Clin Exp Immunol. 1981 Mar;43(3):478-85.
Abstract
Twenty-eight patients with scleroderma were typed for 40 HLA antigens. A highly significant increase in the frequency of HLA-B8 and HLA-DR3 was observed, which was not related to the severity of the disease. In vitro lymphocyte stimulation tests were performed in 26 patients. In addition, humoral and in vitro cellular immune responses to a primary test antigen were measured in 12 of them. Although the group of scleroderma patients as a whole had an impaired cellular response, only the B8/DR3+ patients had a strongly depressed response, whereas the immune response of the others was normal. These findings suggest an association of the haplotype B8/DR3 with impaired cellular immunity.
摘要
对28例硬皮病患者进行了40种HLA抗原分型。观察到HLA - B8和HLA - DR3的频率显著增加，这与疾病的严重程度无关。对26例患者进行了体外淋巴细胞刺激试验。此外，对其中12例患者测量了对一种主要试验抗原的体液和体外细胞免疫反应。虽然硬皮病患者总体上细胞反应受损，但只有B8/DR3 +患者的反应强烈受到抑制，而其他患者的免疫反应正常。这些发现提示单倍型B8/DR3与细胞免疫受损有关。
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