Niu Weiran, Shen Guanglin, Yuan Yuanzhi, Ma Xiaoping, Li Suming, Wang Jingzhao, Fan Zhongyong, Liao Lan
Department of Ophthalmology, Zhongshan Hospital of Fudan University, Shanghai 200032, China.
Institute de High Performance Polymers, Qingdao University of Science and Technology, Qingdao 266042, China.
J Ophthalmol. 2015;2015:737198. doi: 10.1155/2015/737198. Epub 2015 Nov 30.
Purpose. To evaluate the effectiveness and safety of three biodegradable terpolymers prepared from L-lactide, trimethylene carbonate, and glycolide (PTLGA) as an aid for trabeculectomy compared with the Ologen (OLO). Methods. Trabeculectomy was carried out on rabbits with implantation made from OLO or three PTLGA terpolymers. Intraocular pressure (IOP) was recorded 1, 2, 3, and 6 months postoperatively and bleb evaluations were performed using ultrasound biomicroscopy (UBM) 3 months after surgery, optical coherence tomography (OCT) every month, and transmission electron microscopy (TEM) six months after surgery followed by histological examination 1, 2, 3, and 6 months postoperatively. Result. IOP was significantly reduced in all groups after surgery. There were no significant differences in the IOL between groups at any time after implantation. There was no significant difference between the groups examined by OCT, UBM, and TEM. Exposure of the implant was observed in one eye from the OLO group and one eye in the P1. Subconjunctiva hyperblastosis was observed in one eye from group P3 and two eyes from the OLO group. Conclusions. Subconjunctival implantation of filtering devices made from PTLGA may present a safe and effective additional surgical tool for the treatment of filtering surgery. Fewer complications were observed in the group with P2 implants compared to other groups.
目的。评估由L-丙交酯、碳酸三亚甲酯和乙交酯制备的三种可生物降解三元共聚物（PTLGA）作为小梁切除术辅助材料相对于Ologen（OLO）的有效性和安全性。方法。对兔子进行小梁切除术，并植入OLO或三种PTLGA三元共聚物。术后1、2、3和6个月记录眼压（IOP），术后3个月使用超声生物显微镜（UBM）进行滤过泡评估，每月进行光学相干断层扫描（OCT），术后6个月进行透射电子显微镜（TEM）检查，术后1、2、3和6个月进行组织学检查。结果。术后所有组的眼压均显著降低。植入后任何时间组间眼压均无显著差异。OCT、UBM和TEM检查的组间无显著差异。在OLO组的一只眼中和P1组的一只眼中观察到植入物暴露。在P3组的一只眼中和OLO组的两只眼中观察到结膜下细胞增生。结论。结膜下植入由PTLGA制成的滤过装置可能是一种安全有效的用于滤过手术治疗的额外手术工具。与其他组相比，P2植入物组观察到的并发症较少。
