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相似文献

1
Bombesin stimulation of inositol 1,4,5-trisphosphate generation and intracellular calcium release is amplified in a cell line overexpressing the N-ras proto-oncogene.在一个过表达N-ras原癌基因的细胞系中，蛙皮素对肌醇1,4,5-三磷酸生成和细胞内钙释放的刺激作用增强。
Biochem J. 1989 Jun 15;260(3):813-9. doi: 10.1042/bj2600813.
2
Amplification of fluoroaluminate-stimulated inositol phosphate generation in a cell line overexpressing the p21N-ras gene.在过表达p21N-ras基因的细胞系中，氟铝酸盐刺激的肌醇磷酸生成的放大作用。
Biochem J. 1989 May 1;259(3):737-41. doi: 10.1042/bj2590737.
3
Identification of the pertussis and cholera toxin substrates in normal and N-ras transformed NIH3T3 fibroblasts and an assessment of their involvement in bombesin-stimulation of inositol phospholipid metabolism.正常和N-ras转化的NIH3T3成纤维细胞中百日咳毒素和霍乱毒素底物的鉴定及其参与蛙皮素刺激的肌醇磷脂代谢的评估。
Oncogene. 1989 May;4(5):659-63.
4
Inhibition of the amplified bombesin-stimulated inositol phosphate response in N-ras transformed cells by high density culturing.通过高密度培养抑制N-ras转化细胞中增强的蛙皮素刺激的肌醇磷酸反应。
FEBS Lett. 1988 Feb 8;228(1):182-6. doi: 10.1016/0014-5793(88)80613-6.
5
Mechanism of desensitization of the Ca2(+)-mobilizing system to bombesin by Ha-ras. Independence from down-modulation of agonist-stimulated inositol phosphate production.Ha-ras介导的Ca2+动员系统对蛙皮素脱敏的机制。与激动剂刺激的肌醇磷酸生成的下调无关。
J Biol Chem. 1991 Jan 25;266(3):1437-42.
6
Desensitization of the Ca2+-mobilizing system to serum growth factors by Ha-ras and v-mos.Ha-ras和v-mos对血清生长因子的Ca2+动员系统的脱敏作用。
Mol Cell Biol. 1988 Oct;8(10):4212-6. doi: 10.1128/mcb.8.10.4212-4216.1988.
7
Normal p21N-ras couples bombesin and other growth factor receptors to inositol phosphate production.正常的p21N-ras将蛙皮素和其他生长因子受体与肌醇磷酸的产生联系起来。
Nature. 1986;323(6084):173-6. doi: 10.1038/323173a0.
8
PTH elevates inositol polyphosphates and diacylglycerol in a rat osteoblast-like cell line.甲状旁腺激素可提高大鼠成骨样细胞系中的肌醇多磷酸和二酰甘油水平。
Am J Physiol. 1988 Nov;255(5 Pt 1):E660-7. doi: 10.1152/ajpendo.1988.255.5.E660.
9
Effects of bombesin and insulin on inositol (1,4,5)trisphosphate and inositol (1,3,4)trisphosphate formation in Swiss 3T3 cells.蛙皮素和胰岛素对瑞士3T3细胞中肌醇（1,4,5）三磷酸酯和肌醇（1,3,4）三磷酸酯形成的影响。
Cell. 1986 Dec 5;47(5):703-9. doi: 10.1016/0092-8674(86)90513-1.
10
The biphasic stimulation of insulin secretion by bombesin involves both cytosolic free calcium and protein kinase C.蛙皮素对胰岛素分泌的双相刺激涉及胞质游离钙和蛋白激酶C。
Biochem J. 1988 Jul 1;253(1):193-202. doi: 10.1042/bj2530193.

引用本文的文献

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Genomic methods in profiling DNA accessibility and factor localization.基因组学方法在 DNA 可及性和因子定位分析中的应用。
Chromosome Res. 2020 Mar;28(1):69-85. doi: 10.1007/s10577-019-09619-9. Epub 2019 Nov 27.
2
Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease.阿尔茨海默病患者成纤维细胞内的钙离子动员发生改变。
Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):534-8. doi: 10.1073/pnas.91.2.534.
3
Activation of inositol phospholipid breakdown by prostaglandin F2 alpha without any stimulation of proliferation in quiescent NIH-3T3 fibroblasts.前列腺素F2α激活静止的NIH-3T3成纤维细胞中的肌醇磷脂分解，而不刺激其增殖。
Biochem J. 1990 Mar 15;266(3):661-7. doi: 10.1042/bj2660661.
4
Desensitization of prostaglandin F2 alpha-stimulated inositol phosphate generation in NIH-3T3 fibroblasts transformed by overexpression of normal c-Ha-ras-1, c-Ki-ras-2 and c-N-ras genes.在通过正常c-Ha-ras-1、c-Ki-ras-2和c-N-ras基因过表达而转化的NIH-3T3成纤维细胞中，前列腺素F2α刺激的肌醇磷酸生成的脱敏作用。
Biochem J. 1990 May 1;267(3):809-13. doi: 10.1042/bj2670809.
5
Molecular cloning and expression of a G25K cDNA, the human homolog of the yeast cell cycle gene CDC42.酵母细胞周期基因CDC42的人类同源物G25K cDNA的分子克隆与表达
Mol Cell Biol. 1990 Nov;10(11):5977-82. doi: 10.1128/mcb.10.11.5977-5982.1990.

本文引用的文献

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New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures.新型对镁离子和质子具有高选择性的钙指示剂和缓冲剂：原型结构的设计、合成及性质
Biochemistry. 1980 May 27;19(11):2396-404. doi: 10.1021/bi00552a018.
2
Immunocytochemical localization in normal and transformed human cells in tissue culture using a monoclonal antibody to the src protein of the Harvey strain of murine sarcoma virus.使用针对鼠肉瘤病毒哈维株src蛋白的单克隆抗体，在组织培养的正常和转化人细胞中进行免疫细胞化学定位。
Exp Cell Res. 1983 Nov;149(1):141-9. doi: 10.1016/0014-4827(83)90387-7.
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Comparative biochemical properties of normal and activated human ras p21 protein.正常与活化的人源ras p21蛋白的比较生化特性
Nature. 1984;310(5979):644-9. doi: 10.1038/310644a0.
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Primary structure of the alpha-subunit of transducin and its relationship to ras proteins.转导蛋白α亚基的一级结构及其与Ras蛋白的关系。
Nature. 1985;315(6016):242-5. doi: 10.1038/315242a0.
5
The part played by inositol trisphosphate and calcium in the propagation of the fertilization wave in sea urchin eggs.肌醇三磷酸和钙在海胆卵受精波传播中所起的作用。
J Cell Biol. 1986 Dec;103(6 Pt 1):2333-42. doi: 10.1083/jcb.103.6.2333.
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ras genes.RAS基因
Annu Rev Biochem. 1987;56:779-827. doi: 10.1146/annurev.bi.56.070187.004023.
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Inhibition of the amplified bombesin-stimulated inositol phosphate response in N-ras transformed cells by high density culturing.通过高密度培养抑制N-ras转化细胞中增强的蛙皮素刺激的肌醇磷酸反应。
FEBS Lett. 1988 Feb 8;228(1):182-6. doi: 10.1016/0014-5793(88)80613-6.
8
Liberation of [3H]arachidonic acid and changes in cytosolic free calcium in fura-2-loaded human platelets stimulated by ionomycin and collagen.离子霉素和胶原刺激下，用fura-2负载的人血小板中[3H]花生四烯酸的释放及胞质游离钙的变化
Biochem J. 1986 May 1;235(3):869-77. doi: 10.1042/bj2350869.
9
Transformation and stimulation of DNA synthesis in NIH-3T3 cells are a titratable function of normal p21N-ras expression.NIH-3T3细胞中DNA合成的转化和刺激是正常p21N-ras表达的一种可滴定功能。
EMBO J. 1986 Oct;5(10):2617-21. doi: 10.1002/j.1460-2075.1986.tb04542.x.
10
Normal p21N-ras couples bombesin and other growth factor receptors to inositol phosphate production.正常的p21N-ras将蛙皮素和其他生长因子受体与肌醇磷酸的产生联系起来。
Nature. 1986;323(6084):173-6. doi: 10.1038/323173a0.

在一个过表达N-ras原癌基因的细胞系中，蛙皮素对肌醇1,4,5-三磷酸生成和细胞内钙释放的刺激作用增强。

Bombesin stimulation of inositol 1,4,5-trisphosphate generation and intracellular calcium release is amplified in a cell line overexpressing the N-ras proto-oncogene.

作者信息

Lloyd A C, Davies S A, Crossley I, Whitaker M, Houslay M D, Hall A, Marshall C J, Wakelam M J

机构信息

Institute of Cancer Research, Chester Beatty Laboratories, London, U.K.

出版信息

Biochem J. 1989 Jun 15;260(3):813-9. doi: 10.1042/bj2600813.

DOI:10.1042/bj2600813
PMID:2669738
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1138749/
Abstract

Bombesin stimulation of T15 cells in which the inducible N-ras oncogene is overexpressed caused elevated production of inositol phosphates compared to uninduced cells [Wakelam, Davies, Houslay, McKay, Marshall & Hall (1986) Nature (London) 323, 173-176]. This elevated response is shown here to result from increased generation of inositol 1,4,5-trisphosphate leading to an elevated release of intracellular stored Ca2+. Single-cell analysis of Ca2+ release showed that the elevated response is not a consequence of an increased fraction of responding cells. These amplifications are consistent with p21N-ras acting like a guanine nucleotide coupling protein in this cell line.

摘要

与未诱导的细胞相比，用铃蟾肽刺激过表达可诱导型N-ras癌基因的T15细胞，会导致肌醇磷酸产量升高[瓦克莱姆、戴维斯、豪斯利、麦凯、马歇尔和霍尔（1986年），《自然》（伦敦）323, 173 - 176]。此处显示这种升高的反应是由于肌醇1,4,5 - 三磷酸生成增加，导致细胞内储存的Ca2+释放增加。对Ca2+释放的单细胞分析表明，升高的反应不是反应细胞比例增加的结果。这些放大作用与p21N-ras在该细胞系中像鸟嘌呤核苷酸偶联蛋白一样起作用是一致的。