Characterization of botulinum type A neurotoxin gene: delineation of the N-terminal encoding region.
作者信息
Betley M J, Somers E, DasGupta B R
机构信息
Department of Bacteriology, University of Wisconsin, Madison 53706.
出版信息
Biochem Biophys Res Commun. 1989 Aug 15;162(3):1388-95. doi: 10.1016/0006-291x(89)90828-0.
PMID:2669749
Abstract
A 456 basepair HindIII fragment that encoded a portion of the type A botulinum neurotoxin gene was cloned into Escherichia coli using a plasmid vector. DNA sequence analysis revealed that this botulinum DNA insert encoded an open reading frame of 35 amino acid residues of which 34 corresponded to the N-terminal residues of botulinum neurotoxin type A.
摘要
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