Tsuzuki K, Kimura K, Fujii N, Yokosawa N, Oguma K
Department of Microbiology, Sapporo Medical College, Japan.
Biochem Biophys Res Commun. 1992 Mar 31;183(3):1273-9. doi: 10.1016/s0006-291x(05)80328-6.
The structural gene for a nontoxic-nonhemagglutinin component of Clostridium botulinum type C progenitor toxin was found to exist on a 7.8 kb DNA fragment obtained from a type C phage DNA. The gene existed between the neurotoxin and hemagglutinin genes, and consisted of an 3588 bp open reading frame (1196 amino acid residues). It was speculated that this gene and the neurotoxin gene were transcribed by the same mRNA (polycistronic transcription) in C. botulinum organisms.
发现肉毒杆菌C型原毒素无毒非血凝素成分的结构基因存在于从C型噬菌体DNA获得的一个7.8 kb DNA片段上。该基因存在于神经毒素基因和血凝素基因之间，由一个3588 bp的开放阅读框（1196个氨基酸残基）组成。据推测，在肉毒杆菌生物体中，该基因和神经毒素基因由同一mRNA转录（多顺反子转录）。
