直肠残端复发艰难梭菌感染的自行管理家庭系列粪便“微型移植物”。

Self-Administered Home Series Fecal "Minitransplants" for Recurrent Clostridium difficile Infection on a Rectal Remnant.

机构信息

Lucian Blaga University; Polisano Clinic, Sibiu, Romania.

Department of Gastroenterology, Prof. Dr. Octavian Fodor Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca, Romania.

出版信息

J Gastrointestin Liver Dis. 2015 Dec;24(4):531-3. doi: 10.15403/jgld.2014.1121.244.clo.

DOI:10.15403/jgld.2014.1121.244.clo

PMID:26697583

Abstract

A fecal microbiota transplant has proved to be an extremely effective method for patients with recurrent infections with Clostridium difficile. We present the case of a 65-year-old female patient with multiple Clostridium difficile infection (CDI) relapses on the rectal remnant, post-colectomy for a CDI-related toxic megacolon. The patient also evidenced associated symptomatic Clostridium difficile vaginal infection. She was successfully treated with serial fecal "minitransplants" (self-administered at home) and metronidazole ovules.

摘要

粪便微生物群移植已被证明是治疗复发性艰难梭菌感染的一种极其有效的方法。我们报告了一例 65 岁女性患者的病例，她因与艰难梭菌相关的中毒性巨结肠而行结肠切除术，术后直肠残端发生多次艰难梭菌感染 (CDI) 复发。该患者还存在与症状相关的艰难梭菌阴道感染。她通过连续的粪便“微移植”（在家自行给药）和甲硝唑阴道栓治疗后成功治愈。