小鼠中黑质纹状体多巴胺能神经毒素1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）的一些特征。 - Suppr

Some features of the nigrostriatal dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse.

作者信息

Heikkila R E, Sieber B A, Manzino L, Sonsalla P K

机构信息

Department of Neurology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854.

出版信息

Mol Chem Neuropathol. 1989 Jun;10(3):171-83. doi: 10.1007/BF03159727.

DOI:10.1007/BF03159727

PMID:2669769

Abstract

摘要

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Some features of the nigrostriatal dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse.小鼠中黑质纹状体多巴胺能神经毒素1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）的一些特征。

Mol Chem Neuropathol. 1989 Jun;10(3):171-83. doi: 10.1007/BF03159727.

GM1 ganglioside-induced recovery of nigrostriatal dopaminergic neurons after MPTP: an immunohistochemical study.GM1神经节苷脂诱导MPTP后黑质纹状体多巴胺能神经元的恢复：一项免疫组织化学研究

Brain Res. 1989 Apr 10;484(1-2):297-303. doi: 10.1016/0006-8993(89)90373-9.

Synthesis and toxicity toward nigrostriatal dopamine neurons of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) analogues.1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）类似物对黑质纹状体多巴胺能神经元的合成及毒性

J Med Chem. 1986 Mar;29(3):424-7. doi: 10.1021/jm00153a019.

Mechanisms of recovery in MPTP-induced parkinsonism.MPTP 诱导的帕金森症的恢复机制。

Neuroscience. 1988 Nov;27(2):727-9. doi: 10.1016/0306-4522(88)90302-8.

4-phenylpyridine and three other analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine lack dopaminergic nigrostriatal neurotoxicity in mice and marmosets.

Neurosci Lett. 1987 Mar 20;75(1):65-70. doi: 10.1016/0304-3940(87)90076-0.

Primate model of parkinsonism: selective lesion of nigrostriatal neurons by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine produces an extrapyramidal syndrome in rhesus monkeys.帕金森病灵长类动物模型：1-甲基-4-苯基-1,2,3,6-四氢吡啶对黑质纹状体神经元的选择性损伤在恒河猴中产生锥体外系综合征。

Life Sci. 1985 Jan 21;36(3):213-8. doi: 10.1016/0024-3205(85)90061-x.

Immunohistochemical evaluation of the neurotoxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on dopaminergic nigrostriatal neurons of young adult mice using dopamine and tyrosine hydroxylase antibodies.使用多巴胺和酪氨酸羟化酶抗体对1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）对成年小鼠多巴胺能黑质纹状体神经元的神经毒性作用进行免疫组织化学评估。

Neurosci Lett. 1988 Jul 19;90(1-2):57-62. doi: 10.1016/0304-3940(88)90786-0.

MPTP produces a pattern of nigrostriatal degeneration which coincides with the mosaic organization of the caudate nucleus.

Brain Res. 1988 Nov 8;473(1):60-4. doi: 10.1016/0006-8993(88)90315-0.

Ro 16-6491: a new reversible and highly selective MAO-B inhibitor protects mice from the dopaminergic neurotoxicity of MPTP.Ro 16-6491：一种新型可逆性且高选择性的单胺氧化酶B抑制剂可保护小鼠免受1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）的多巴胺能神经毒性。

Adv Neurol. 1987;45:175-8.

Paraquat and two endogenous analogues of the neurotoxic substance N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine do not damage dopaminergic nigrostriatal neurons in the mouse.百草枯以及神经毒性物质N-甲基-4-苯基-1,2,3,6-四氢吡啶的两种内源性类似物不会损伤小鼠的多巴胺能黑质纹状体神经元。

Neurosci Lett. 1986 Sep 12;69(3):285-9. doi: 10.1016/0304-3940(86)90495-7.

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Motor Neurons Pathology After Chronic Exposure to MPTP in Mice.慢性暴露于 MPTP 后小鼠运动神经元病理学

Neurotox Res. 2020 Feb;37(2):298-313. doi: 10.1007/s12640-019-00121-y. Epub 2019 Nov 13.

Targeted deletion of the aquaglyceroporin AQP9 is protective in a mouse model of Parkinson's disease.靶向敲除水通道蛋白 aquaglyceroporin AQP9 对帕金森病小鼠模型具有保护作用。

PLoS One. 2018 Mar 22;13(3):e0194896. doi: 10.1371/journal.pone.0194896. eCollection 2018.

Brain structural changes in cynomolgus monkeys administered with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: A longitudinal voxel-based morphometry and diffusion tensor imaging study.给予1-甲基-4-苯基-1,2,3,6-四氢吡啶的食蟹猴脑结构变化：一项基于体素的纵向形态测量和扩散张量成像研究

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Pain perception in acute model mice of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）诱导的帕金森病急性模型小鼠的疼痛感知

Mol Pain. 2015 May 17;11:28. doi: 10.1186/s12990-015-0026-1.

The yeast product Milmed enhances the effect of physical exercise on motor performance and dopamine neurochemistry recovery in MPTP-lesioned mice.酵母产物 Milmed 增强了运动对 MPTP 损伤小鼠运动表现和多巴胺神经化学恢复的影响。

Neurotox Res. 2013 Oct;24(3):393-406. doi: 10.1007/s12640-013-9405-4. Epub 2013 Jul 27.

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Some features of the nigrostriatal dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse.

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