Faggion Clovis Mariano
Department of Periodontology and Operative Dentistry, Faculty of Dentistry, University of Münster, Waldeyerstraße 30, 48149 Münster, Germany.
J Evid Based Dent Pract. 2015 Dec;15(4):164-70. doi: 10.1016/j.jebdp.2015.09.002.
This first article of a series of 4 is aimed at guiding dental practitioners on how to evaluate the internal validity (risk of bias,) of randomized controlled trials (RCT). All RCT's contain different areas and potential sources of bias. Understanding risk of bias (ROB) will allow dental practitioners to improve the quality of dental treatments.
The following areas of bias were elucidated: sequence generation, allocation concealment, blinding of participants and personnel, blinding of outcome assessment, incomplete outcome data, selective reporting, and "other bias". The reader determines the ROB level by evaluating the areas or potential source of bias in the first phase. Normally, ROB levels are classified as low, high and unclear ROB.
This article reported the concepts and methods of evaluation of ROB in several areas of an RCT. An RCT with low ROB in all evaluated areas gives the dental practitioners more certainty and confidence that a specific clinical procedure is in fact effective and relevant to the patient.
The information provided here may guide dental practitioners in the evaluation of ROB in an RCT. The correct evaluation of ROB may improve the quality of dental treatments.
本系列共4篇文章中的第一篇旨在指导牙科从业者如何评估随机对照试验（RCT）的内部有效性（偏倚风险）。所有随机对照试验都包含不同的偏倚领域和潜在来源。了解偏倚风险（ROB）将使牙科从业者能够提高牙科治疗的质量。
阐明了以下偏倚领域：随机序列生成、分配隐藏、参与者和人员的盲法、结果评估的盲法、不完整的结果数据、选择性报告以及“其他偏倚”。读者在第一阶段通过评估偏倚领域或潜在来源来确定ROB水平。通常，ROB水平分为低、高和不明确的ROB。
本文报告了随机对照试验几个领域中ROB的评估概念和方法。在所有评估领域中ROB较低的随机对照试验，能让牙科从业者更确定且更有信心认为特定临床程序实际上是有效的且与患者相关。
此处提供的信息可能会指导牙科从业者评估随机对照试验中的ROB。对ROB的正确评估可能会提高牙科治疗的质量。
