体外乙醇未能抑制下丘脑释放促性腺激素释放激素。

Failure of in vitro ethanol to inhibit LHRH release from the hypothalamus.

作者信息

Emanuele M A, Tentler J, Reda D, Kirsteins L, Emanuele N V, Lawrence A M

机构信息

Research and Medical Services, Veterans Administration Hospital, Hines, IL 60141.

出版信息

Alcohol. 1989 Jul-Aug;6(4):263-6. doi: 10.1016/0741-8329(89)90080-3.

DOI:10.1016/0741-8329(89)90080-3

PMID:2669840

Abstract

The reproductive alterations induced by ethanol (ETOH) in the male rodent have been intensively investigated. Although gonadal effects are well characterized, the impact of ETOH on the hypothalamic peptide luteinizing hormone-releasing hormone (LHRH) has been less well defined. The releasability of hypothalamic LHRH in the presence of ETOH has not been directly studied. We report here that ETOH in concentrations of 50 mg% to 400 mg% failed to inhibit LHRH release in vitro.

摘要

乙醇（ETOH）对雄性啮齿动物生殖功能的影响已得到深入研究。尽管性腺效应已得到充分表征，但ETOH对下丘脑肽促黄体生成激素释放激素（LHRH）的影响仍不太明确。ETOH存在时下丘脑LHRH的释放能力尚未得到直接研究。我们在此报告，浓度为50mg%至400mg%的ETOH在体外未能抑制LHRH的释放。