卡介苗感染后小鼠组织中磷脂脂肪酸组成和三酰甘油含量的变化
Changes in phospholipid fatty acid composition and triacylglycerol content in mouse tissues after infection with bacille Calmette-Guérin.
作者信息
Jackson S K, Stark J M, Taylor S, Harwood J L
机构信息
Department of Medical Microbiology University of Wales College of Medicine, Cardiff, UK.
出版信息
Br J Exp Pathol. 1989 Aug;70(4):435-41.
Abstract
Changes in the lipids of tissues from mice infected with bacille Calmette-Guérin (BCG) have been detected by gas-liquid chromatography. Infection with BCG resulted in (1) an increase in the polyunsaturated to saturated fatty acid ratio of phospholipids and (2) a decrease in the total triacylglycerol fatty acid content of spleen, liver and peritoneal macrophages. The alteration in fatty acid composition was significant in the phosphatidylethanolamine fraction of the phospholipids. The relation of these findings to an increased sensitivity to bacterial endotoxins is discussed.
摘要
已通过气液色谱法检测了感染卡介苗（BCG）的小鼠组织中的脂质变化。感染卡介苗导致：（1）磷脂中多不饱和脂肪酸与饱和脂肪酸的比例增加；（2）脾脏、肝脏和腹膜巨噬细胞中总三酰甘油脂肪酸含量降低。脂肪酸组成的变化在磷脂的磷脂酰乙醇胺部分中很显著。讨论了这些发现与对细菌内毒素敏感性增加之间的关系。
相似文献
1
Changes in phospholipid fatty acid composition and triacylglycerol content in mouse tissues after infection with bacille Calmette-Guérin.
Br J Exp Pathol. 1989 Aug;70(4):435-41.
2
The effect of endotoxin on membrane fatty acid composition in BCG-sensitized mice.
Experientia. 1990 May 15;46(5):472-4. doi: 10.1007/BF01954235.
3
Quantification of fatty acids as methyl esters and phospholipids in cheese samples after separation of triacylglycerides and phospholipids.
Anal Chim Acta. 2009 Mar 23;636(2):229-35. doi: 10.1016/j.aca.2009.01.056. Epub 2009 Feb 5.
4
[Value of preparative thin-layer chromatography in the separation and study of the fatty acid composition of various lipid fractions].
Ann Biol Clin (Paris). 1972;30(2):153-9.
5
Effect of acute streptozotocin diabetes on fatty acid content and composition in different lipid fractions of rat skeletal muscle.
Horm Metab Res. 1999 Apr;31(4):252-6. doi: 10.1055/s-2007-978727.
6
Immune response to Mycobacterium bovis bacille Calmette Guérin infection in major histocompatibility complex class I- and II-deficient knock-out mice: contribution of CD4 and CD8 T cells to acquired resistance.
Eur J Immunol. 1995 Feb;25(2):377-84. doi: 10.1002/eji.1830250211.
7
Lipid composition in human breast milk from Granada (Spain): changes during lactation.
Nutrition. 2005 Apr;21(4):467-73. doi: 10.1016/j.nut.2004.08.020.
8
Developing rod photoreceptors from normal and mutant Rd mouse retinas: altered fatty acid composition early in development of the mutant.
J Neurosci Res. 1988;20(2):202-11. doi: 10.1002/jnr.490200209.
9
Inhibition of inducible nitric oxide synthase protects against liver injury induced by mycobacterial infection and endotoxins.
J Hepatol. 2004 Nov;41(5):773-81. doi: 10.1016/j.jhep.2004.07.031.
10
Dietary trans fatty acids alter diaphragm phospholipid fatty acid composition, triacylglycerol content and glucose transport in rats.
Br J Nutr. 2005 Jun;93(6):829-33. doi: 10.1079/BJN20051442.
引用本文的文献
1
Fatty acid desaturation and lipoxygenase pathways support trained immunity.
Nat Commun. 2023 Nov 15;14(1):7385. doi: 10.1038/s41467-023-43315-x.
2
Galleria mellonella-intracellular bacteria pathogen infection models: the ins and outs.
FEMS Microbiol Rev. 2023 Mar 10;47(2). doi: 10.1093/femsre/fuad011.
3
Global adaptation to a lipid environment triggers the dormancy-related phenotype of Mycobacterium tuberculosis.
mBio. 2014 May 20;5(3):e01125-14. doi: 10.1128/mBio.01125-14.
4
Lipids in host-pathogen interactions: pathogens exploit the complexity of the host cell lipidome.
Prog Lipid Res. 2010 Jan;49(1):1-26. doi: 10.1016/j.plipres.2009.07.003. Epub 2009 Jul 26.
5
A novel in vitro multiple-stress dormancy model for Mycobacterium tuberculosis generates a lipid-loaded, drug-tolerant, dormant pathogen.
PLoS One. 2009 Jun 29;4(6):e6077. doi: 10.1371/journal.pone.0006077.
6
Macrophage activation by lipopolysaccharide, interferon-gamma and interleukin-4: effect of fatty acid metabolism.
Mediators Inflamm. 1995;4(1):25-30. doi: 10.1155/S0962935195000056.
7
Functional role of the PE domain and immunogenicity of the Mycobacterium tuberculosis triacylglycerol hydrolase LipY.
Infect Immun. 2008 Jan;76(1):127-40. doi: 10.1128/IAI.00410-07. Epub 2007 Oct 15.
8
Identification of a diacylglycerol acyltransferase gene involved in accumulation of triacylglycerol in Mycobacterium tuberculosis under stress.
Microbiology (Reading). 2006 Sep;152(Pt 9):2717-2725. doi: 10.1099/mic.0.28993-0.
9
A novel lipase belonging to the hormone-sensitive lipase family induced under starvation to utilize stored triacylglycerol in Mycobacterium tuberculosis.
J Biol Chem. 2006 Feb 17;281(7):3866-75. doi: 10.1074/jbc.M505556200. Epub 2005 Dec 13.
10
The effect of endotoxin on membrane fatty acid composition in BCG-sensitized mice.
Experientia. 1990 May 15;46(5):472-4. doi: 10.1007/BF01954235.
本文引用的文献
1
The rapid incorporation of phosphate into mitochondrial lipids.
J Biol Chem. 1963 Jan;238:59-63.
2
Phospholipid composition of human monocytes and alterations occurring due to culture and stimulation by C3b.
Biochim Biophys Acta. 1984 Jul 20;804(3):301-7. doi: 10.1016/0167-4889(84)90133-2.
3
Unsaturated fatty acids as second messengers of superoxide generation by macrophages.
Cell Immunol. 1983 Jul 15;79(2):240-52. doi: 10.1016/0008-8749(83)90067-9.
4
Identification of 4-hydroxynonenal as a cytotoxic product originating from the peroxidation of liver microsomal lipids.
Biochim Biophys Acta. 1980 Nov 7;620(2):281-96. doi: 10.1016/0005-2760(80)90209-x.
5
Rate of antigen catabolism and immunogenicity of [131-I]BGG in mice. I. Action of mycobacterial adjuvants.
Immunology. 1970 Sep;19(3):449-56.
6
Leukotriene D4 mediates galactosamine/endotoxin-induced hepatitis in mice.
Biochem Pharmacol. 1987 Jun 15;36(12):1867. doi: 10.1016/0006-2952(87)90482-5.
7
Changes in the incorporation of free fatty acids upon the stimulation of human polymorphonuclear leukocytes.
J Leukoc Biol. 1986 Mar;39(3):267-84. doi: 10.1002/jlb.39.3.267.
8
Arachidonic acid metabolism.
Annu Rev Biochem. 1986;55:69-102. doi: 10.1146/annurev.bi.55.070186.000441.
9
Phospholipid metabolism of stimulated lymphocytes. Composition of phospholipid fatty acids.
Biochim Biophys Acta. 1975 Sep 19;398(3):364-76. doi: 10.1016/0005-2760(75)90187-3.
10
Effects of BCG infection on the susceptibility of mouse macrophages to endotoxin.
Infect Immun. 1979 Apr;24(1):59-64. doi: 10.1128/iai.24.1.59-64.1979.
Zotero 插件