卡介苗感染后小鼠组织中磷脂脂肪酸组成和三酰甘油含量的变化
Changes in phospholipid fatty acid composition and triacylglycerol content in mouse tissues after infection with bacille Calmette-Guérin.
作者信息
Jackson S K, Stark J M, Taylor S, Harwood J L
机构信息
Department of Medical Microbiology University of Wales College of Medicine, Cardiff, UK.
出版信息
Br J Exp Pathol. 1989 Aug;70(4):435-41.
Abstract
Changes in the lipids of tissues from mice infected with bacille Calmette-Guérin (BCG) have been detected by gas-liquid chromatography. Infection with BCG resulted in (1) an increase in the polyunsaturated to saturated fatty acid ratio of phospholipids and (2) a decrease in the total triacylglycerol fatty acid content of spleen, liver and peritoneal macrophages. The alteration in fatty acid composition was significant in the phosphatidylethanolamine fraction of the phospholipids. The relation of these findings to an increased sensitivity to bacterial endotoxins is discussed.
摘要
已通过气液色谱法检测了感染卡介苗（BCG）的小鼠组织中的脂质变化。感染卡介苗导致：（1）磷脂中多不饱和脂肪酸与饱和脂肪酸的比例增加；（2）脾脏、肝脏和腹膜巨噬细胞中总三酰甘油脂肪酸含量降低。脂肪酸组成的变化在磷脂的磷脂酰乙醇胺部分中很显著。讨论了这些发现与对细菌内毒素敏感性增加之间的关系。
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