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The effect of endotoxin on membrane fatty acid composition in BCG-sensitized mice.

作者信息

Stark J M, Jackson S K, Taylor S, Davies I, Harwood J L

机构信息

Department of Medical Microbiology, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom.

出版信息

Experientia. 1990 May 15;46(5):472-4. doi: 10.1007/BF01954235.

DOI:10.1007/BF01954235
PMID:2347397
Abstract

The effects of endotoxin on mouse liver phospholipid fatty acid composition have been investigated. Administration of endotoxin from Salmonella abortus equi led to a decrease in the polyunsaturated fatty acid content of livers from mice sensitized with Bacille Calmette Guérin (BCG). The content of arachidonic acid fell significantly in both the phosphatidylcholine and phosphatidylinositol fractions whereas in the phosphatidylethanolamine fraction the linoleic acid content was significantly reduced. The polyunsaturated fatty acids were replaced by increased amounts of oleic acid and palmitic acid, leading to a reduction in the polyunsaturated to saturated fatty acid ratio.

摘要

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引用本文的文献

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本文引用的文献

1
The rapid incorporation of phosphate into mitochondrial lipids.磷酸盐迅速掺入线粒体脂质中。
J Biol Chem. 1963 Jan;238:59-63.
2
Hyperreactivity to endotoxin in mice infected with mycobacteria. Induction and elicitation of the reactions.感染分枝杆菌的小鼠对内毒素的高反应性。反应的诱导与激发。
Immunology. 1961 Oct;4(4):354-65.
3
Evidence for pulmonary release of 5-hydroxyeicosatetraenoic acid (5-hete) during endotoxemia in unanesthetized sheep.未麻醉绵羊内毒素血症期间肺释放5-羟基二十碳四烯酸（5-HETE）的证据。
Prostaglandins. 1982 Apr;23(4):459-68. doi: 10.1016/0090-6980(82)90109-5.
4
The role of prostaglandins in sepsis.前列腺素在脓毒症中的作用。
Scand J Infect Dis Suppl. 1982;31:55-60.
5
Phospholipid composition of membranes in the tumor cell.肿瘤细胞膜中的磷脂成分。
Biochim Biophys Acta. 1970 Jul 14;210(2):287-98. doi: 10.1016/0005-2760(70)90173-6.
6
Is platelet activating factor (PAF) a mediator of endotoxin shock?血小板活化因子（PAF）是内毒素休克的介质吗？
Eur J Pharmacol. 1985 Feb 26;109(2):257-61. doi: 10.1016/0014-2999(85)90427-3.
7
Requirement for lipopolysaccharide-responsive macrophages in galactosamine-induced sensitization to endotoxin.半乳糖胺诱导的内毒素致敏中对脂多糖反应性巨噬细胞的需求。
Infect Immun. 1986 Mar;51(3):891-5. doi: 10.1128/iai.51.3.891-895.1986.
8
Hepatocyte function in sepsis: Kupffer cells mediate a biphasic protein synthesis response in hepatocytes after exposure to endotoxin or killed Escherichia coli.脓毒症中的肝细胞功能：库普弗细胞在内毒素或灭活大肠杆菌刺激后介导肝细胞的双相蛋白质合成反应。
Surgery. 1985 Sep;98(3):388-95.
9
Changes in phospholipid fatty acid composition and triacylglycerol content in mouse tissues after infection with bacille Calmette-Guérin.卡介苗感染后小鼠组织中磷脂脂肪酸组成和三酰甘油含量的变化
Br J Exp Pathol. 1989 Aug;70(4):435-41.