Reischies Frederike M J, Raggam Reinhard B, Prattes Juergen, Krause Robert, Eigl Susanne, List Agnes, Quehenberger Franz, Strenger Volker, Wölfler Albert, Hoenigl Martin
Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria
J Clin Microbiol. 2016 Mar;54(3):771-4. doi: 10.1128/JCM.02969-15. Epub 2015 Dec 23.
Galactomannan (GM) testing of urine specimens may provide important advantages, compared to serum testing, such as easy noninvasive sample collection. We evaluated a total of 632 serial urine samples from 71 patients with underlying hematological malignancies and found that the urine GM/creatinine ratio, i.e., (urine GM level × 100)/urine creatinine level, which takes urine dilution into account, reliably detected invasive aspergillosis and may be a promising diagnostic tool for patients with hematological malignancies. (This study has been registered at ClinicalTrials.gov under registration no. NCT01576653.).
与血清检测相比，尿液标本的半乳甘露聚糖（GM）检测可能具有重要优势，比如样本采集简便、无创。我们评估了71例血液系统恶性肿瘤患者的632份连续尿液样本，发现考虑尿液稀释因素的尿液GM/肌酐比值，即（尿液GM水平×100）/尿液肌酐水平，能够可靠地检测侵袭性曲霉病，对于血液系统恶性肿瘤患者而言可能是一种很有前景的诊断工具。（本研究已在ClinicalTrials.gov注册，注册号为NCT01576653。）
