血小板活化因子：一种生殖植入前阶段的旁分泌因子？

Platelet-activating factor: a paracrine factor in preimplantation stages of reproduction?

作者信息

Harper M J

机构信息

Department of Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio 78284-7836.

出版信息

Biol Reprod. 1989 May;40(5):907-13. doi: 10.1095/biolreprod40.5.907.

DOI:10.1095/biolreprod40.5.907

PMID:2669984

Abstract

Platelet-activating factor (PAF) exerts its actions through activation of specific membrane binding sites found in a variety of tissues, including hypothalamus and endometrium. PAF has been identified in several reproductive tissues (i.e. embryo, ovary, uterus, and spermatozoon). In the uterus, PAF levels are hormonally controlled, being elevated by progesterone and prostaglandin E2 (PGE2). Antagonists of PAF interfere with sperm function, ovulation, and implantation. The available evidence suggests that PAF may be an important physiological regulator in reproduction.

摘要

血小板活化因子（PAF）通过激活多种组织（包括下丘脑和子宫内膜）中发现的特定膜结合位点来发挥其作用。PAF已在多种生殖组织（即胚胎、卵巢、子宫和精子）中被鉴定出来。在子宫中，PAF水平受激素控制，孕酮和前列腺素E2（PGE2）可使其升高。PAF拮抗剂会干扰精子功能、排卵和着床。现有证据表明，PAF可能是生殖过程中的一种重要生理调节因子。