非胶原蛋白基质蛋白及其在矿化中的作用。

Noncollagenous matrix proteins and their role in mineralization.

作者信息

Boskey A L

机构信息

Laboratory for Ultrastructural Biochemistry, Hospital for Special Surgery, New York, NY 10021.

出版信息

Bone Miner. 1989 May;6(2):111-23. doi: 10.1016/0169-6009(89)90044-5.

DOI:10.1016/0169-6009(89)90044-5

PMID:2670018

Abstract

Improved technologies have led to the isolation of a large number of noncollagenous matrix proteins from the mineralized connective tissues. These proteins have been postulated to have many functions, but few of their suggested roles have been verified. Many of the noncollagenous matrix proteins are thought to regulate the deposition of hydroxyapatite mineral. In this review the current information on the role of these proteins in the mineralized and mineralizing connective tissues is presented along with a synopsis of the methods currently being used to elucidate these functions.

摘要

改进的技术已使得从矿化结缔组织中分离出大量非胶原蛋白基质蛋白成为可能。这些蛋白被推测具有多种功能，但它们所提出的作用中仅有少数得到了证实。许多非胶原蛋白基质蛋白被认为可调节羟基磷灰石矿物质的沉积。在这篇综述中，将呈现关于这些蛋白在矿化和正在矿化的结缔组织中作用的当前信息，以及目前用于阐明这些功能的方法概要。