Adefegha Stephen A, Omojokun Olasunkanmi S, Oboh Ganiyu, Fasakin Olasunkanmi, Ogunsuyi Opeyemi
Federal University of Technology, Akure, Ondo State, Nigeria.
Federal University of Technology, Akure, Ondo State, Nigeria
J Evid Based Complementary Altern Med. 2016 Oct;21(4):NP56-61. doi: 10.1177/2156587215621726. Epub 2015 Dec 23.
Studies have shown the pharmacological relevance of phenolics like ferulic acid (FA) in promoting health. This study sought to investigate the modulatory effects of FA on cadmium-induced brain damage in rats. Brain damage was induced in Wistar strain rats by oral administration of cadmium (5 mg/kg body weight) for 21 days. Assays for malondialdehyde (MDA) content, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), monoamine oxidase (MAO), and Na(+)/K(+)-ATPase activities were carried out. The study revealed significant (P < .05) increases in the MDA content and all enzymes' (AChE, BChE, MAO, and Na(+)/K(+)-ATPase) activity investigated following cadmium administration. However, rats administered FA (10 and 20 mg/kg body weight) alongside cadmium significantly (P < .05) protected the brain by reversing the level of lipid peroxidation as measured by the MDA content as well as the enzymes' activity. This study, therefore, substantiates the neuroprotective potentials of FA especially in the management of cadmium-induced toxicity.
研究表明，阿魏酸（FA）等酚类物质在促进健康方面具有药理学相关性。本研究旨在探讨FA对镉诱导的大鼠脑损伤的调节作用。通过给Wistar品系大鼠口服镉（5毫克/千克体重）21天来诱导脑损伤。进行了丙二醛（MDA）含量、乙酰胆碱酯酶（AChE）、丁酰胆碱酯酶（BChE）、单胺氧化酶（MAO）和钠钾ATP酶（Na(+)/K(+)-ATPase）活性的测定。研究显示，镉给药后，所研究的MDA含量以及所有酶（AChE、BChE、MAO和Na(+)/K(+)-ATPase）的活性均显著（P < 0.05）增加。然而，与镉同时给予FA（10和20毫克/千克体重）的大鼠通过逆转以MDA含量衡量的脂质过氧化水平以及酶的活性，显著（P < 0.05）保护了大脑。因此，本研究证实了FA的神经保护潜力，尤其是在镉诱导的毒性管理方面。
