Department of Biochemistry, Covenant University, Ota, Nigeria.
Department of Biochemistry, College of Sciences, Afe Babalola University, Ado-Ekiti, Nigeria.
J Int Med Res. 2020 Jun;48(6):300060520922649. doi: 10.1177/0300060520922649.
This study was designed to evaluate the protective effect of aqueous extract of Linn leaf in the brain of an alloxan-induced rat model of diabetes.
The experimental model of diabetes was induced by a single intraperitoneal injection of freshly prepared alloxan. Rats were then divided into six groups: normal control, diabetes control, diabetes group treated with metformin, and three diabetes groups treated with different concentrations of . Rats were sacrificed on day 14 of the experiment and different brain biochemical parameters were assessed and compared between groups.
Administration of different doses of leaf aqueous extract was associated with significantly reduced levels of fasting blood glucose, lipid peroxidation, neurotransmitters, cholinesterases, cyclooxygenase-2 and nitric oxide compared with diabetes control rats. In addition, antioxidant enzyme activities were significantly increased in diabetes rats administered 12.45, 24.9 and 49.8 mg/kg body weight of versus diabetes control rats.
Aqueous extract of Linn leaf may be useful in the management of diabetic neuropathy.
本研究旨在评估 Linn 叶的水提物对丙烯醛诱导的糖尿病大鼠模型大脑的保护作用。
通过单次腹腔注射新鲜制备的丙烯醛诱导实验性糖尿病模型。然后，将大鼠分为六组：正常对照组、糖尿病对照组、糖尿病组用二甲双胍治疗，以及用不同浓度 Linn 叶水提物治疗的三组糖尿病大鼠。在实验第 14 天处死大鼠，评估并比较各组之间的不同脑生化参数。
与糖尿病对照组大鼠相比，给予不同剂量 Linn 叶水提物后，空腹血糖、脂质过氧化、神经递质、胆碱酯酶、环加氧酶-2 和一氧化氮水平显著降低。此外，与糖尿病对照组大鼠相比，给予 12.45、24.9 和 49.8 mg/kg 体重的 Linn 叶水提物的糖尿病大鼠的抗氧化酶活性显著增加。
Linn 叶的水提物可能有助于糖尿病神经病变的治疗。
