Liu T H
Zhonghua Yi Xue Za Zhi. 1989 Feb;69(2):83-5, 8.
Pancreatic tissues from 40 autopsies of diabetes mellitus and 10 surgically resected non-diabetic pancreatic specimens were studied morphologically and immunocytochemically. Slides were stained for insulin(B), glucagon(A), somatostatin(D), and pancreatic polypeptide (PP) producing cells using immunocytochemistry. Morphometric study disclosed a significant decrease in the number of B-cells and a relative increase in the number of A cells, the A/B ratio shifted from 1:2.3 in controls to 1:0.9 in diabetics. No significant change was found in the number of D and PP cells in diabetics as compared with those in controls. The results of this study have further proved the presence of B cell reduction in diabetic patients.
对40例糖尿病患者尸检的胰腺组织以及10例手术切除的非糖尿病胰腺标本进行了形态学和免疫细胞化学研究。采用免疫细胞化学方法对胰岛素（B）、胰高血糖素（A）、生长抑素（D）和胰多肽（PP）产生细胞的玻片进行染色。形态计量学研究显示B细胞数量显著减少，A细胞数量相对增加，A/B比值从对照组的1:2.3转变为糖尿病患者的1:0.9。与对照组相比，糖尿病患者的D细胞和PP细胞数量未发现显著变化。本研究结果进一步证实了糖尿病患者存在B细胞减少。
