Li Liangzhu, Chen Keqiang, Xiang Yi, Yoshimura Teizo, Su Shaobo, Zhu Jianwei, Bian Xiu-wu, Wang Ji Ming
*Engineering Research Center of Cell and Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China; Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA; Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China; Department of Pulmonary Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University, Chongqing, China; and Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
*Engineering Research Center of Cell and Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China; Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA; Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China; Department of Pulmonary Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University, Chongqing, China; and Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
J Leukoc Biol. 2016 Mar;99(3):425-35. doi: 10.1189/jlb.2RI0815-354RR. Epub 2015 Dec 23.
Formyl-peptide receptors are a family of 7 transmembrane domain, Gi-protein-coupled receptors that possess multiple functions in many pathophysiologic processes because of their expression in a variety of cell types and their capacity to interact with a variety of structurally diverse, chemotactic ligands. Accumulating evidence demonstrates that formyl-peptide receptors are critical mediators of myeloid cell trafficking in the sequential chemotaxis signal relays in microbial infection, inflammation, and immune responses. Formyl-peptide receptors are also involved in the development and progression of cancer. In addition, one of the formyl-peptide receptor family members, Fpr2, is expressed by normal mouse-colon epithelial cells, mediates cell responses to microbial chemotactic agonists, participates in mucosal development and repair, and protects against inflammation-associated tumorigenesis. These novel discoveries greatly expanded the current understanding of the role of formyl-peptide receptors in host defense and as potential molecular targets for the development of therapeutics.
甲酰肽受体是一类7次跨膜结构域的G蛋白偶联受体，由于它们在多种细胞类型中的表达以及与多种结构不同的趋化配体相互作用的能力，在许多病理生理过程中具有多种功能。越来越多的证据表明，甲酰肽受体是微生物感染、炎症和免疫反应中连续趋化信号转导过程中髓样细胞迁移的关键介质。甲酰肽受体也参与癌症的发生和发展。此外，甲酰肽受体家族成员之一Fpr2，由正常小鼠结肠上皮细胞表达，介导细胞对微生物趋化激动剂的反应，参与黏膜发育和修复，并预防炎症相关的肿瘤发生。这些新发现极大地扩展了目前对甲酰肽受体在宿主防御中的作用以及作为治疗药物开发潜在分子靶点的理解。
