丙型肝炎病毒感染作为帕金森病的一个危险因素：一项全国性队列研究。
Hepatitis C virus infection as a risk factor for Parkinson disease: A nationwide cohort study.
作者信息
Tsai Hsin-Hsi, Liou Horng-Huei, Muo Chih-Hsin, Lee Cha-Ze, Yen Ruoh-Fang, Kao Chia-Hung
机构信息
From the Departments of Neurology (H.-H.T.), Neurology and Pharmacology (H.-H.L.), Internal Medicine (C.-Z.L.), and Nuclear Medicine (R.-F.Y.), National Taiwan University Hospital, Taipei; College of Medicine, National Taiwan University (H.-H.L., C.-Z.L.), Taipei; Management Office for Health Data (C.-H.M.) and Department of Nuclear Medicine and PET Center (C.-H.K.), China Medical University Hospital, Taichung; College of Medicine (C.-H.M.), China Medical University, Taichung; Department of Radiology (R.-F.Y.), National Taiwan University College of Medicine, Taipei; Graduate Institute of Clinical Medical Science and School of Medicine (C.-H.K.), College of Medicine, China Medical University, Taichung, Taiwan.
出版信息
Neurology. 2016 Mar 1;86(9):840-6. doi: 10.1212/WNL.0000000000002307. Epub 2015 Dec 23.
OBJECTIVE
To determine whether hepatitis C virus (HCV) infection is a risk factor for developing Parkinson disease (PD).
METHODS
This nationwide population-based cohort study was based on data obtained from a dataset of the Taiwan National Health Insurance Research Database for the period 2000 to 2010. A total of 49,967 patients with viral hepatitis were included for analysis. Furthermore, 199,868 people without viral hepatitis were included for comparisons. Patients with viral hepatitis were further grouped into 3 cohorts: hepatitis B virus (HBV) infection, HCV infection, and HBV-HCV coinfection. In each cohort, we calculated the incidence of developing PD. A Cox proportional hazards model was applied to estimate the risk of developing PD in terms of hazard ratios (HRs) and 95% confidence intervals (CIs).
RESULTS
The crude HRs for developing PD was 0.66 (95% CI = 0.55-0.80) for HBV infection, 2.50 (95% CI = 2.07-3.02) for HCV infection, and 1.28 (95% CI = 0.88-1.85) for HBV-HCV coinfection. The association between HCV and PD remained statistically significant after adjustments for age, sex, and comorbidities (adjusted HR = 1.29, 95% CI = 1.06-1.56).
CONCLUSIONS
We conducted a large nationwide population-based study and found that patients with HCV exhibit a significantly increased risk of developing PD.
目的
确定丙型肝炎病毒（HCV）感染是否为帕金森病（PD）发生的危险因素。
方法
这项基于全国人群的队列研究的数据来自2000年至2010年台湾国民健康保险研究数据库。共纳入49967例病毒性肝炎患者进行分析。此外，纳入199868例无病毒性肝炎的患者作为对照。病毒性肝炎患者进一步分为3个队列：乙型肝炎病毒（HBV）感染、HCV感染和HBV-HCV合并感染。在每个队列中，我们计算了发生PD的发病率。应用Cox比例风险模型以风险比（HRs）和95%置信区间（CIs）估计发生PD的风险。
结果
HBV感染发生PD的粗HR为0.66（95%CI = 0.55 - 0.80），HCV感染为2.50（95%CI = 2.07 - 3.02），HBV-HCV合并感染为1.28（95%CI = 0.88 - 1.85）。在对年龄、性别和合并症进行调整后，HCV与PD之间的关联仍具有统计学意义（调整后HR = 1.29，95%CI = 1.06 - 1.56）。
结论
我们进行了一项基于全国人群的大型研究，发现HCV患者发生PD的风险显著增加。
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