Parkinson's Disease and Movement Disorders Clinic, Bangalore, India; Center for Parkinson's Disease and Movement Disorders, Manipal Hospital, Miller's Road, Bangalore, India.
Int Rev Neurobiol. 2022;165:251-262. doi: 10.1016/bs.irn.2022.06.007. Epub 2022 Jul 22.
Parkinson's disease (PD) is one of the most common age-related disorders globally. The pathophysiological mechanisms and precipitating factors underlying PD manifestations, including genetic and environmental parameters, inflammation/stress and ageing, remain elusive. Speculations about whether the Coronavirus Disease 2019 (Covid-19) pandemic could be a pivotal factor in affecting the prevalence and severity of PD or triggering a wave of new-onset parkinsonism in both the near and distant future have recently become very popular, with researchers wondering if there is a changing trend in current parkinsonism cases. Could the current understanding of the Covid-19 pathophysiology provide clues for an impending rise of parkinsonism cases in the future? Are there any lessons to learn from previous pandemics? Our aim was to look into these questions and available current literature in order to investigate if Covid-19 could constitute a cardinal event affecting the parkinsonism landscape.
帕金森病（PD）是全球最常见的与年龄相关的疾病之一。帕金森病表现背后的病理生理机制和促成因素，包括遗传和环境参数、炎症/应激和衰老，仍然难以捉摸。关于 2019 年冠状病毒病（COVID-19）大流行是否可能成为影响 PD 患病率和严重程度的关键因素，或者是否会在不久的将来引发新的帕金森病发作的猜测，最近变得非常流行，研究人员想知道目前帕金森病病例是否有变化趋势。目前对 COVID-19 病理生理学的理解是否能为未来帕金森病病例的增加提供线索？从前的大流行中是否有可以借鉴的经验教训？我们的目的是探讨这些问题和现有的文献，以研究 COVID-19 是否可能成为影响帕金森病发病模式的重要事件。
