Verdoodt Freija, Friis Søren, Dehlendorff Christian, Albieri Vanna, Kjaer Susanne K
Unit of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
Unit of Statistics, Bioinformatics and Registry, Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, University of Copenhagen, Copenhagen, and Department of Clinical Epidemiology, Faculty of Health, Aarhus University Hospital, Aarhus, Denmark.
Gynecol Oncol. 2016 Feb;140(2):352-8. doi: 10.1016/j.ygyno.2015.12.009. Epub 2015 Dec 14.
Non-steroidal anti-inflammatory drug (NSAID) use has been linked to a reduction in the risk of several cancer types. For endometrial cancer, however, results have been inconsistent. To summarize the available evidence on the risk of endometrial cancer associated with use of aspirin or non-aspirin (NA-) NSAIDs, we performed a systematic review and meta-analysis of observational studies.
We conducted a bibliographic database search in PubMed, Embase and Cochrane Library. Relative risk estimates were extracted from eligible case-control and cohort studies and pooled using a random effects model.
Six case-control and seven cohort studies were found eligible for our meta-analysis. We observed risk reductions in endometrial cancer associated with regular use of aspirin (case-control: 11%, cohort: 8%) and NA-NSAIDs (case-control: 9%, cohort: 6%), compared to non-use. However, the pooled risk ratios were not statistically significant. Higher risk reductions were seen with high frequency of notably aspirin use (case-control: 37%, cohort: 20%). The inverse association between regular aspirin use and endometrial cancer risk was strongest among women with a body mass index above 30 (case-control: 44%, cohort: 20%).
Regular use of aspirin or NA-NSAIDs was associated with a marginally reduced risk of endometrial cancer. Larger risk reductions were linked with high frequency of NSAID use and high BMI.
非甾体抗炎药（NSAID）的使用与多种癌症类型风险的降低有关。然而，对于子宫内膜癌，结果并不一致。为总结与使用阿司匹林或非阿司匹林（NA-）NSAIDs相关的子宫内膜癌风险的现有证据，我们对观察性研究进行了系统评价和荟萃分析。
我们在PubMed、Embase和Cochrane图书馆进行了文献数据库检索。从符合条件的病例对照研究和队列研究中提取相对风险估计值，并使用随机效应模型进行汇总。
发现六项病例对照研究和七项队列研究符合我们的荟萃分析条件。与未使用者相比，我们观察到经常使用阿司匹林（病例对照：11%，队列：8%）和NA-NSAIDs（病例对照：9%，队列：6%）与子宫内膜癌风险降低有关。然而，汇总的风险比无统计学意义。阿司匹林使用频率较高时，风险降低幅度更大（病例对照：37%，队列：20%）。经常使用阿司匹林与子宫内膜癌风险之间的负相关在体重指数高于30的女性中最为明显（病例对照：44%，队列：20%）。
经常使用阿司匹林或NA-NSAIDs与子宫内膜癌风险略有降低有关。NSAID使用频率较高和体重指数较高与更大的风险降低相关。
