关于鼓膜与锤骨之间的连接。
On the connection between the tympanic membrane and the malleus.
作者信息
De Greef Daniel, Goyens Jana, Pintelon Isabel, Bogers John-Paul, Van Rompaey Vincent, Hamans Evert, Van de Heyning Paul, Dirckx Joris J J
机构信息
Laboratory of Biomedical Physics, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium.
Laboratory of Biomedical Physics, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium; Laboratory of Functional Morphology, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium.
出版信息
Hear Res. 2016 Oct;340:50-59. doi: 10.1016/j.heares.2015.12.002. Epub 2015 Dec 15.
BACKGROUND
The tympano-mallear connection (TMC) is the soft-tissue connection between the tympanic membrane (TM) and the manubrium of the malleus. Some studies suggest that its mechanical properties may have a substantial influence on the mechanics and transfer function of the middle ear. However, relatively little is known about the dimensions of the TMC and its variability among individuals.
METHOD
Thirteen samples were collected from human temporal bones, consisting of only the malleus and the TM. They were imaged using μCT without contrast enhancing agent. From the μCT images, the TMC dimensions were measured in both anterior-posterior direction (TMC width) and medial-lateral direction (TMC thickness). Three selected samples were examined using histological microscopy.
RESULTS
Both TMC width and thickness featured a large variability among individuals. The minimal TMC width along the manubrium for different individuals covered a range between 83 and 840 μm. The minimal thickness ranged from 48 to 249 μm and the maximal thickness from 236 to 691 μm. Histological sections showed that the TMC consists of a narrow core of dense regular connective tissue, surrounded by loose connective tissue. In some samples, either of these two components was absent in the TMC at some manubrium locations. The configuration of these components varied among the samples as well.
CONCLUSION
Our data confirm that a large inter-individual variability exists in the properties of the TM-malleus connection in humans in terms of its dimensions, tissue composition and configuration. Average data and their variability margins will be useful input for testing the importance of the TMC in finite element models.
背景
鼓室-锤骨连接（TMC）是鼓膜（TM）与锤骨柄之间的软组织连接。一些研究表明，其力学性能可能对中耳的力学和传递功能有重大影响。然而，关于TMC的尺寸及其个体间的变异性，人们了解得相对较少。
方法
从人类颞骨中收集了13个样本，仅包括锤骨和TM。使用无造影剂的μCT对其进行成像。从μCT图像中，在前后方向（TMC宽度）和内外方向（TMC厚度）测量TMC尺寸。对三个选定的样本进行组织学显微镜检查。
结果
TMC的宽度和厚度在个体间均表现出很大的变异性。不同个体沿锤骨柄的最小TMC宽度范围在83至840μm之间。最小厚度范围为48至249μm，最大厚度范围为236至691μm。组织学切片显示，TMC由致密规则结缔组织的狭窄核心组成，周围是疏松结缔组织。在一些样本中，在锤骨柄的某些位置，这两种成分中的任何一种在TMC中都不存在。这些成分的构型在样本之间也有所不同。
结论
我们的数据证实，人类TM-锤骨连接在尺寸、组织组成和构型方面的特性存在很大的个体间变异性。平均数据及其变异范围将为测试TMC在有限元模型中的重要性提供有用的输入。
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