Gezer Naciye Sinem, Güleryüz Handan, Gezer Cenk, Koçyiğit Ali, Yeşilırmak Didem, Ekin Atalay, Bilgin Muzaffer, Ertaş İbrahim Egemen
Department of Radiology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey.
Turk J Pediatr. 2015 May-Jun;57(3):266-71.
In this prospective study, we aimed to establish the value of volumetric assessment by prenatal brain MRI in determining the prognosis of fetuses with isolated VM. A total of 23 fetuses with isolated VM were included in the study. Supratentorial cerebral parenchyma volume (PV) and ventricular volume (VV) were measured, and supratentorial ventricular/parenchymal volume (VV/PV) ratios were calculated. Pregnancy and postnatal neurodevelopmental outcomes up to two years of age were obtained and correlated with the volumetric measurements. VV was found to be strongly and positively correlated with ventricular dimension. There was a statistically significant difference between the VV/ PV ratios of the good and poor prognosis groups into which the cases had been categorized. The fetuses with a poor prognosis had a significantly higher VV/PV ratio. Volumetric parenchymal and ventricular measurements obtained by fetal brain MRI may contribute to future clinical studies concerning the evaluation of fetuses with VM and provide an important indicator in cases where management dilemmas arise.
在这项前瞻性研究中，我们旨在确定产前脑磁共振成像（MRI）容积评估在孤立性脑中线结构发育异常（VM）胎儿预后判断中的价值。本研究共纳入23例孤立性VM胎儿。测量幕上脑实质体积（PV）和脑室体积（VV），并计算幕上脑室/脑实质体积（VV/PV）比值。获取妊娠及产后至两岁的神经发育结局，并将其与容积测量结果进行关联分析。发现VV与脑室大小呈强正相关。病例分类后的预后良好组和预后不良组的VV/PV比值存在统计学显著差异。预后不良的胎儿VV/PV比值显著更高。胎儿脑MRI获得的脑实质和脑室容积测量结果可能有助于未来关于VM胎儿评估的临床研究，并在出现管理难题的病例中提供重要指标。
