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酪氨酸转氨酶的磷酸化与其由环磷酸腺苷和激素介导的合成调节之间的关系。

Relationship between phosphorylation of tyrosine aminotransferase and regulation of its synthesis by cyclic AMP and hormones.

作者信息

Wicks W D, Su J L

出版信息

J Cyclic Nucleotide Res. 1978 Apr;4(2):113-22.

PMID:26702
Abstract

Tyrosine adminotransferase (EC 2.6.1.5) has been found to be phosphorylated in intact rat hepatoma cells in culture. Incorporation of [32p]i into the enzyme is rapid and is exclusively found as phosphoserine. Cycloheximide treatment reduced phosphorylation of the aminotransferase only slightly and in the presence of three different inducers of this enzyme, dexamethasone, insulin, and dibutyryl cyclic AMP, [32P]I incorporation was increased. It is concluded that [32p]i incorporation into this enzyme probably reflects turnover of phosphate groups associated with pre-existing enzyme molecules catalyzed by a cyclic AMP-independent protein kinase.

摘要

酪氨酸转氨酶（EC 2.6.1.5）已被发现在培养的完整大鼠肝癌细胞中发生磷酸化。[32P]i掺入该酶的过程迅速，且仅以磷酸丝氨酸的形式存在。环己酰亚胺处理仅轻微降低了转氨酶的磷酸化，并且在该酶的三种不同诱导剂地塞米松、胰岛素和二丁酰环磷酸腺苷存在的情况下，[32P]i掺入增加。得出的结论是，[32P]i掺入该酶可能反映了由一种不依赖环磷酸腺苷的蛋白激酶催化的与预先存在的酶分子相关的磷酸基团的周转。

相似文献

1
Relationship between phosphorylation of tyrosine aminotransferase and regulation of its synthesis by cyclic AMP and hormones.酪氨酸转氨酶的磷酸化与其由环磷酸腺苷和激素介导的合成调节之间的关系。
J Cyclic Nucleotide Res. 1978 Apr;4(2):113-22.
2
Phosphorylation of tyrosine hydroxylase on at least three sites in rat pheochromocytoma PC12 cells treated with 56 mM K+: determination of the sites on tyrosine hydroxylase phosphorylated by cyclic AMP-dependent and calcium/calmodulin-dependent protein kinases.用56 mM K⁺处理的大鼠嗜铬细胞瘤PC12细胞中酪氨酸羟化酶至少三个位点的磷酸化：确定环磷酸腺苷依赖性蛋白激酶和钙/钙调蛋白依赖性蛋白激酶磷酸化的酪氨酸羟化酶位点
Mol Pharmacol. 1986 Nov;30(5):476-85.
3
Induction of ornithine decarboxylase in Reuber H35 rat hepatoma cells.鲁伯H35大鼠肝癌细胞中鸟氨酸脱羧酶的诱导
J Cyclic Nucleotide Res. 1976;2(4):241-50.
4
Is cyclic AMP dependent protein kinase responsible for the in vivo phosphorylation of tyrosine aminotransferase?环磷酸腺苷依赖性蛋白激酶是否负责酪氨酸转氨酶的体内磷酸化？
J Cyclic Nucleotide Protein Phosphor Res. 1986;11(5):395-406.
5
Interaction between hormones and cyclic AMP in regulating specific hepatic enzyme synthesis.激素与环磷酸腺苷在调节特定肝酶合成中的相互作用。
Fed Proc. 1974 Apr;33(4):1105-11.
6
Multihormonal control of tyrosine aminotransferase in isolated liver cells.分离肝细胞中酪氨酸转氨酶的多激素调控
Monogr Endocrinol. 1979;12:219-41. doi: 10.1007/978-3-642-81265-1_12.
7
Coordinate protein kinase activation and specific enzyme induction by cyclic nucleotide derivatives in intact cultured hepatoma cells.在完整的培养肝癌细胞中，通过环核苷酸衍生物协调蛋白激酶激活和特定酶诱导。
Mol Pharmacol. 1979 Sep;16(2):449-61.
8
Interaction of glucocorticoid hormones and cyclic nucleotides in induction of tyrosine aminotransferase in cultured hepatoma cells.糖皮质激素与环核苷酸在培养的肝癌细胞中诱导酪氨酸转氨酶的相互作用。
J Biol Chem. 1977 Jun 10;252(11):3891-7.
9
Regulation of cAMP metabolism, protein kinase activation, and specific enzyme synthesis in cultured hepatoma cells.
Adv Cyclic Nucleotide Res. 1978;9:411-24.
10
Glucocorticoid requirement for tyrosine aminotransferase induction by adenosine 3':5'-cyclic phosphate analogs in somatic cell hybrids.
Arch Biochem Biophys. 1978 Jan 30;185(2):525-34. doi: 10.1016/0003-9861(78)90197-2.

引用本文的文献

1
Phenylalanine hydroxylase in liver cells. Correlation of glucagon-stimulated enzyme phosphorylation with expressed activity.肝细胞中的苯丙氨酸羟化酶。胰高血糖素刺激的酶磷酸化与表达活性的相关性。
Biochem J. 1984 Apr 1;219(1):79-85. doi: 10.1042/bj2190079.
2
The influence of starvation and tryptophan administration on the metabolism of phenylalanine, tyrosine and tryptophan in isolated rat liver cells.饥饿和给予色氨酸对离体大鼠肝细胞中苯丙氨酸、酪氨酸和色氨酸代谢的影响。
Biochem J. 1984 Jul 15;221(2):431-8. doi: 10.1042/bj2210431.
3
Regulation of the synthesis of tyrosine aminotransferase: the relationship to mRNATAT.
酪氨酸转氨酶合成的调节：与mRNA TAT的关系。
Mol Cell Biochem. 1983;53-54(1-2):113-28. doi: 10.1007/BF00225249.
4
Differences in rates of tyrosine aminotransferase deinduction with cyclic AMP and glucocorticoids.环磷酸腺苷和糖皮质激素对酪氨酸转氨酶去诱导作用速率的差异。
Proc Natl Acad Sci U S A. 1982 Oct;79(19):5778-82. doi: 10.1073/pnas.79.19.5778.
5
Phosphopeptide analysis of phenylalanine hydroxylase isolated from liver cells exposed to hormonal stimuli.对从暴露于激素刺激的肝细胞中分离出的苯丙氨酸羟化酶进行磷酸肽分析。
Biochem J. 1986 Jan 15;233(2):507-11. doi: 10.1042/bj2330507.
6
The effect of streptozotocin-induced diabetes on phenylalanine hydroxylase expression in rat liver.链脲佐菌素诱导的糖尿病对大鼠肝脏苯丙氨酸羟化酶表达的影响。
Biochem J. 1989 Nov 15;264(1):185-90. doi: 10.1042/bj2640185.