Granner D K, Hargrove J L
Mol Cell Biochem. 1983;53-54(1-2):113-28. doi: 10.1007/BF00225249.
The activity of the hepatic enzyme tyrosine aminotransferase (TAT) is the sum of many diverse regulatory factors. These include the developmental stage of the animal, the hormonal and nutritional environment of the animal (or tissue culture cell), other extrinsic and intrinsic regulatory cycles and factors (including cytoplasmic substances), and chromatin structure. Although TAT is subject to a number of post-translational modifications, alterations in catalytic activity always parallel changes in enzyme amount. In a few instances this is due to a selective change in TAT degradation, but most are due to changes in the rate of aminotransferase synthesis. Recent studies have shown that TAT synthesis is generally directly correlated with the activity, and presumably amount, of the mRNA that codes for tyrosine aminotransferase.
肝酶酪氨酸转氨酶（TAT）的活性是多种不同调节因子作用的总和。这些调节因子包括动物的发育阶段、动物（或组织培养细胞）的激素和营养环境、其他外在和内在的调节周期及因子（包括细胞质物质）以及染色质结构。尽管TAT会经历多种翻译后修饰，但催化活性的改变总是与酶量的变化平行。在少数情况下，这是由于TAT降解的选择性变化所致，但大多数情况是由于转氨酶合成速率的改变。最近的研究表明，TAT的合成通常与编码酪氨酸转氨酶的mRNA的活性以及推测的量直接相关。
