通过烷基化反应合成苯并咪唑-2-硫酮衍生物及其晶体结构
Synthesis and Crystal Structures of Benzimidazole-2-thione Derivatives by Alkylation Reactions.
作者信息
El Ashry El Sayed H, El Kilany Yeldez, Nahas Nariman M, Barakat Assem, Al-Qurashi Nadia, Ghabbour Hazem A, Fun Hoong-Kun
机构信息
Chemistry Department, Faculty of Science, Alexandria University, P. O. Box 426, Alexandria 21321, Egypt.
Chemistry Department, Faculty of Applied Science, Umm Al-Qura University, Makkah 21955, Saudi Arabia.
出版信息
Molecules. 2015 Dec 22;21(1):E12. doi: 10.3390/molecules21010012.
Alkylated, benzylated and bromoalkylated benzimidazole-thione that intramolecularly heterocyclized to 3,4-dihydro-2H-[1,3]thiazino[3,2-a]benzimidazole were synthesized. The chemical structure of the synthesized product was characterized by Infra Red, ¹H-NMR, (13)C-NMR, and Mass spectroscopy. Furthermore, the molecular structures of 8 and 9 were confirmed by X-ray single crystallography in different space groups, Pbca and P2₁/c, respectively.
合成了分子内杂环化为3,4-二氢-2H-[1,3]噻嗪并[3,2-a]苯并咪唑的烷基化、苄基化和溴烷基化苯并咪唑硫酮。通过红外光谱、¹H-NMR、(13)C-NMR和质谱对合成产物的化学结构进行了表征。此外，8和9的分子结构分别通过X射线单晶衍射在不同空间群Pbca和P2₁/c中得到了确证。
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