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一种简便高效的合成新型苯并咪唑-2-硫酮衍生物的方法。

A facile and efficient procedure for the synthesis of new benzimidazole-2-thione derivatives.

机构信息

Departamento de Química, Facultad de Ciencias, Universidad Nacional de Colombia, Sede Bogotá, Cra.30 No.45-03, Bogotá 111321, Colombia.

出版信息

Molecules. 2012 Jul 17;17(7):8578-86. doi: 10.3390/molecules17078578.

DOI:10.3390/molecules17078578
PMID:22805508
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6268960/
Abstract

A series of benzimidazole-2-thione derivatives was synthesized using a reaction between the macrocyclic aminal 16H,13H-5:12,7:14-dimethanedibenzo[d,i]-[1,3,6,8] tetraazecine (DMDBTA, 5) and various nucleophiles in the presence of carbon disulfide. A full chemical characterization using IR, ¹H-, ¹³C-NMR and GC-MS analyses of the new compounds is provided. These compounds were separated from the reaction mixture by column chromatography (CC) in highly pure form in 15%-51.4% yield.

摘要

一系列苯并咪唑-2-硫酮衍生物是通过大环亚胺 16H，13H-5：12，7：14-二甲撑二苯并[d，i]-[1，3，6，8]四氮杂环十四烷（DMDBTA，5）与各种亲核试剂在二硫化碳存在下反应合成的。通过红外光谱（IR）、¹H-、¹³C-NMR 和 GC-MS 分析对新化合物进行了全面的化学表征。这些化合物通过柱色谱（CC）从反应混合物中以高纯度形式分离，产率为 15%-51.4%。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9147/6268960/c495cfb43c88/molecules-17-08578-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9147/6268960/c37bf5afe8f0/molecules-17-08578-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9147/6268960/f153e4ddce29/molecules-17-08578-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9147/6268960/c495cfb43c88/molecules-17-08578-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9147/6268960/c37bf5afe8f0/molecules-17-08578-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9147/6268960/f153e4ddce29/molecules-17-08578-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9147/6268960/c495cfb43c88/molecules-17-08578-g003.jpg

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