Piazzesi G, Morano I, Rüegg J C
Department of Physiology II, University of Heidelberg, Fed. Rep. of Germany.
Arzneimittelforschung. 1987 Oct;37(10):1141-3.
The influence of two benzimidazole derivatives, 2-[(2-methoxy-4-methylsulfinyl)phenyl]-1H-imidazo [4,5-b] pyridine (sulmazole, AR-L 115 BS) and 4,5-dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl- 3(2H)- pyridazinone (pimobendan, UD-CG 115 BS) on the Ca2+-dependent isometric tension of skinned frog skeletal muscle fibres (tibialis anterior of Rana esculenta) was investigated. Both drugs sensitized the myofibrils of skeletal muscle for Ca2+: at a drug concentration of 2 X 10(-4) mol/l, sulmazole and pimobendan increased the isometric tension obtained at a Ca2+ concentration of 10(-6) mol/l by 21.7% and 49%, respectively.
研究了两种苯并咪唑衍生物，2-[(2-甲氧基-4-甲亚磺酰基)苯基]-1H-咪唑并[4,5-b]吡啶（舒马唑，AR-L 115 BS）和4,5-二氢-6-[2-(4-甲氧基苯基)-1H-苯并咪唑-5-基]-5-甲基-3(2H)-哒嗪酮（匹莫苯丹，UD-CG 115 BS）对去表皮青蛙骨骼肌纤维（食用蛙胫前肌）的钙依赖性等长张力的影响。两种药物均使骨骼肌肌原纤维对钙离子敏感：在药物浓度为2×10(-4) mol/l时，舒马唑和匹莫苯丹分别使在钙离子浓度为10(-6) mol/l时获得的等长张力增加了21.7%和49%。
