荧光3-肉桂酰香豆素的合成及其传感应用

Synthesis and Sensing Applications of Fluorescent 3-Cinnamoyl Coumarins.

作者信息

Yadav Preeti, Gill Hardeep Singh, Chand Karam, Li Lian, Kumar Jayant, Sharma Sunil K

机构信息

Department of Chemistry, University of Delhi, Delhi 110007, India.

Center for Advanced Materials, University of Massachusetts Lowell, Lowell, MA 01854, USA.

出版信息

Sensors (Basel). 2015 Dec 19;15(12):31987-98. doi: 10.3390/s151229902.

DOI:10.3390/s151229902

PMID:26703600

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4721820/

Abstract

We have synthesized two novel fluorescent 3-(4-diethylaminocinnamoyl) coumarins that exhibit fluorescence quenching upon exposure to a nerve agent simulant, diethylchlorophosphate (DCP), providing a basis for rapid and sensitive DCP chemosensing. Furthermore, these coumarin derivatives display two-photon fluorescence upon illumination with near-infrared laser pulses and their two-photon (TP) absorption cross-section was evaluated. The potential for TP bio-imaging of these compounds was investigated by their cellular uptake in HeLa cells by TP confocal microscopy.

摘要

我们合成了两种新型荧光3-(4-二乙氨基肉桂酰基)香豆素，它们在暴露于神经毒剂模拟物磷酸二乙酯（DCP）时会发生荧光猝灭，为快速灵敏的DCP化学传感提供了基础。此外，这些香豆素衍生物在近红外激光脉冲照射下显示双光子荧光，并对其双光子（TP）吸收截面进行了评估。通过共聚焦显微镜观察这些化合物在HeLa细胞中的摄取情况，研究了它们进行双光子生物成像的潜力。