Lyn Jinghuan, Wang Yanfen, Wang Feng, Shen Minghong, Zhou Xiaojun
Department of Pathology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
E-mail:
Zhonghua Bing Li Xue Za Zhi. 2015 Aug;44(8):578-81.
To study the diagnostic value of SATB2, together with CK7 and CK20, in colorectal cancer.
Immunohistochemical study for SATB2, CK7 and CK20 was carried out in 210 cases of colorectal cancer tissue, 100 cases of non-colorectal cancer tissue, 90 cases of lymph node metastases and 50 cases of normal colorectal mucosa.
The sensitivity and specificity of CK20+/CK7- immunophenotype for diagnosis of colorectal adenocarcinoma were 78.1% and 92.0%, respectively. When triple markers were used, the immunophenotype CK20+/CK7-/SATB2+ had a sensitivity of 57.1% and a specificity of 98.0%. When combining the immunophenotype of SATB2+/CK7- or CK20+/CK7-, the sensitivity was 85.7% and specificity was 90.0%.
A panel of immunohistochemical markers SATB2, CK7 and CK20 could increase the specificity for diagnosis of colorectal adenocarcinoma significantly. SATB2 is considered as a useful adjunct in this respect.
研究SATB2联合细胞角蛋白7（CK7）和细胞角蛋白20（CK20）在结直肠癌中的诊断价值。
对210例结直肠癌组织、100例非结直肠癌组织、90例淋巴结转移灶及50例正常结直肠黏膜进行SATB2、CK7和CK20的免疫组织化学研究。
CK20+/CK7-免疫表型诊断结直肠腺癌的敏感性和特异性分别为78.1%和92.0%。使用三联标记物时，CK20+/CK7-/SATB2+免疫表型的敏感性为57.1%，特异性为98.0%。联合SATB2+/CK7-或CK20+/CK7-免疫表型时，敏感性为85.7%，特异性为90.0%。
一组免疫组织化学标记物SATB2、CK7和CK20可显著提高结直肠腺癌诊断的特异性。在这方面，SATB2被认为是一种有用的辅助标记物。
