Zeng Hongjun, Yin Wei, Catausan Grace, Moldovan Nicolaie, Carlisle John
Advanced Diamond Technologies, Inc. 48 E Belmont Drive, Romeoville, IL 60446, USA.
Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794.
Diam Relat Mater. 2016 Jan 1;61:97-101. doi: 10.1016/j.diamond.2015.11.020.
In this report, an idea of integrating ultrananocrystalline diamond (UNCD) with pyrolytic carbon (PyC) -based mechanical heart valves, has been demonstrated. The report addresses the strategies to avoid graphitization and film delamination during the diamond coating. Raman and scratch tests showed that a UNCD film with high purity could adhere to the PyC substrate strongly. A thrombin generation study demonstrated an excellent biocompatibility of UNCD towards fresh human platelets. These results suggest that UNCD could be a good candidate of surface material for next generation heart valves and other implantable devices.
在本报告中，已展示了将超纳米晶金刚石（UNCD）与基于热解碳（PyC）的机械心脏瓣膜相结合的想法。该报告阐述了在金刚石涂层过程中避免石墨化和薄膜分层的策略。拉曼和划痕测试表明，高纯度的UNCD薄膜能够牢固地附着在PyC基底上。凝血酶生成研究证明了UNCD对新鲜人血小板具有优异的生物相容性。这些结果表明，UNCD可能是下一代心脏瓣膜和其他可植入装置表面材料的良好候选者。
