Oolbekkink M, Heine R J, den Hollander W, Nauta J J, van der Veen E A
Department of Endocrinology, Free University Hospital, Amsterdam, The Netherlands.
Eur J Nucl Med. 1989;15(6):292-5. doi: 10.1007/BF00435468.
Insulin binding kinetics in the liver were studied in non insulin dependent (Type 2) diabetic patients, by i.v. bolus administration of 123I-insulin. Eight Type 2 diabetic patients were compared with six male volunteers. Uptake of 123I-insulin by liver and kidneys was measured by dynamic scintigraphy with a gamma camera during 30 min. Images of liver and kidneys appeared within 2-3 min after administration of 123I-insulin at a dose of 1 mCi (37 MBq). Peak radioactivity for the liver was found 7.5 +/- 0.2 and 6.9 +/- 0.3 min after injection for the healthy and the diabetic subjects, respectively (N.S.). The percentage 123I-insulin hepatic uptake was not significantly different for the diabetic and the healthy subjects. Although a large variation exists for maximal uptake of radioactivity within both groups, the data suggest that binding differences in the liver in Type 2 diabetic patients, as compared to healthy subjects, may not account for hepatic insulin resistance.
通过静脉推注123I-胰岛素，对非胰岛素依赖型（2型）糖尿病患者肝脏中的胰岛素结合动力学进行了研究。将8名2型糖尿病患者与6名男性志愿者进行了比较。在30分钟内，使用γ相机通过动态闪烁显像测量肝脏和肾脏对123I-胰岛素的摄取。在以1毫居里（37兆贝可）的剂量注射123I-胰岛素后2至3分钟内出现肝脏和肾脏的图像。健康受试者和糖尿病受试者在注射后分别于7.5±0.2分钟和6.9±0.3分钟出现肝脏放射性峰值（无显著性差异）。糖尿病受试者和健康受试者的123I-胰岛素肝脏摄取百分比无显著差异。尽管两组内放射性最大摄取量存在很大差异，但数据表明，与健康受试者相比，2型糖尿病患者肝脏中的结合差异可能不是肝脏胰岛素抵抗的原因。
