Sinclair A J, Signore A, Bomanji J, Britton K E, Pozzilli P, Gale E A
Department of Diabetes, St Bartholomew's Hospital, West Smithfield, London, UK.
Nucl Med Commun. 1987 Oct;8(10):779-86. doi: 10.1097/00006231-198710000-00003.
Radioactive tracer techniques using 131I- and 125I-insulin have been applied to study insulin metabolism. A simple method to label human insulin with 123I to a high specific activity is described. We have used this radiotracer to study insulin kinetics in vivo in normal subjects and in two groups of diabetic patients. The rate of decline in plasma radioactivity was shown to be significantly reduced in patients with diabetes. There were no significant differences in the time-activity profiles of liver and kidneys between the groups studied. This technique may provide insight into the mechanism of some forms of insulin resistance.
使用¹³¹I和¹²⁵I标记的胰岛素的放射性示踪技术已被应用于研究胰岛素代谢。本文描述了一种用¹²³I将人胰岛素标记至高比活度的简单方法。我们已使用这种放射性示踪剂来研究正常受试者以及两组糖尿病患者体内的胰岛素动力学。结果显示，糖尿病患者血浆放射性的下降速率显著降低。在所研究的组之间，肝脏和肾脏的时间-活性曲线没有显著差异。这项技术可能有助于深入了解某些形式胰岛素抵抗的机制。
