Kovac S, Alferink J, Ahmetspahic D, Arolt V, Melzer N
Klinik für Allgemeine Neurologie mit Institut für Translationale Neurologie, Universitätsklinikum Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Deutschland.
Cluster of Excellence EXC 1003, Cells in Motion, Universität Münster, Münster, Deutschland.
Nervenarzt. 2018 Jan;89(1):99-112. doi: 10.1007/s00115-017-0405-0.
Autoimmune encephalitis is a group of autoimmune inflammatory disorders affecting both grey and white matter of the central nervous system. Encephalitis with autoantibodies against the N‑methyl-D-aspartate receptor (NMDA-R) is the most frequent autoimmune encephalitis syndrome presenting with a characteristic sequence of psychiatric and neurological symptoms. Treatment necessitates a close interdisciplinary cooperation. This article provides an update on the current knowledge on diagnostic standards, pathogenesis, and treatment strategies for anti-NMDA-R encephalitis from psychiatric and neurological perspectives.
自身免疫性脑炎是一组影响中枢神经系统灰质和白质的自身免疫性炎症性疾病。抗N-甲基-D-天冬氨酸受体（NMDA-R）自身抗体所致的脑炎是最常见的自身免疫性脑炎综合征，具有特征性的精神和神经症状序列。治疗需要密切的多学科合作。本文从精神科和神经科角度提供了关于抗NMDA-R脑炎诊断标准、发病机制和治疗策略的最新知识。
