靶向纳米系统：用于癌症治疗的靶向树枝状大分子的进展
Targeted nanosystems: Advances in targeted dendrimers for cancer therapy.
作者信息
Yang Hu
机构信息
Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA, USA; Department of Pharmaceutics, Virginia Commonwealth University, Richmond, VA, USA; Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
出版信息
Nanomedicine. 2016 Feb;12(2):309-16. doi: 10.1016/j.nano.2015.11.012. Epub 2015 Dec 17.
UNLABELLED
Dendrimers possess discrete highly compact nanostructures constituted of successive branched layers. Soon after the inception of dendrimers, recognition of their tunable structures and biologically favorable properties provoked a great enthusiasm in delving deeply into the utility of dendrimers for biomedical and pharmaceutical applications. One of the most important nanotechnology applications is the development of nanomedicines for targeted cancer therapies. Tremendous success in targeted therapies has been achieved with the use of dendrimer-based nanomedicines. This article provides a concise review on latest advances in the utility of dendrimers in immunotherapies and hormone therapies.
FROM THE CLINICAL EDITOR
Much basic and clinical research has been done since the invention of dendrimers, which are highly branched nano-sized molecules with the ability to act as carriers in nanomedicine. In this concise review article, the authors highlighted the current use of dendrimers in immunotherapies and hormone therapies in the fight against cancers.
未标注
树枝状大分子具有由连续分支层构成的离散高度紧凑纳米结构。在树枝状大分子诞生后不久，对其可调节结构和生物学有利特性的认识激发了人们深入探究树枝状大分子在生物医学和制药应用中的效用的极大热情。最重要的纳米技术应用之一是开发用于靶向癌症治疗的纳米药物。使用基于树枝状大分子的纳米药物在靶向治疗方面取得了巨大成功。本文简要综述了树枝状大分子在免疫治疗和激素治疗中的最新应用进展。
来自临床编辑
自树枝状大分子发明以来，已经进行了许多基础和临床研究，树枝状大分子是高度分支的纳米级分子，能够在纳米医学中充当载体。在这篇简要综述文章中，作者强调了树枝状大分子目前在对抗癌症的免疫治疗和激素治疗中的应用。
Zotero 插件