McCullagh P
John Curtin School of Medical Research, Australian National University, Canberra.
Immunology. 1989 Aug;67(4):489-95.
Fetal lambs of 53-55 days gestation invariably failed to accept skin allografts from fetal donors of similar age but retained allografts from adult donors. Autografts of skin were accepted by 53-55-day fetuses. When the survival of allografts transplanted from fetal donors of a range of gestational ages was examined, skin from fetuses of up to 85 days was rejected but that from a 95-day donor was retained. Histological examination of fetal skin allografts revealed that these were subject to lymphocytic invasion, evident as the entry of lymphatic vessels and extravasation of lymphocytes within the first week after placement. These manifestations of an allograft reaction became more prominent during the following 2 weeks, with graft rejection being evident by the end of a month. Allografts of adult skin were subject to occasional focal lymphocytic infiltration but otherwise healed in uneventfully.
妊娠53 - 55天的胎羊总是不能接受来自同龄胎儿供体的皮肤同种异体移植，但能保留来自成年供体的同种异体移植。53 - 55天的胎儿能接受自体皮肤移植。当检查从一系列不同胎龄的胎儿供体移植的同种异体移植的存活情况时，来自85天及以下胎儿的皮肤被排斥，但来自95天供体的皮肤被保留。对胎儿皮肤同种异体移植的组织学检查显示，这些移植受到淋巴细胞浸润，表现为淋巴管在植入后第一周内进入以及淋巴细胞外渗。同种异体移植反应的这些表现在接下来的2周内变得更加明显，到一个月末移植排斥明显。成年皮肤同种异体移植偶尔会有局灶性淋巴细胞浸润，但其他方面愈合顺利。
