SILVERSTEIN A M, PRENDERGAST R A, KRANER K L
J Exp Med. 1964 Jan 1;119(6):955-64. doi: 10.1084/jem.119.6.955.
The fetal lamb was found to reject orthotopic skin homografts applied at any time after the 77th day of gestation. Prior to this, grafts remained in place without stimulating any detectable immunologic response. Once the fetus achieves the ability to reject the graft, the process occurs with the same competence and rapidity as in the adult. Graft rejection in the fetal lamb is unaccompanied by formation of plasma cells or by the production of typical immunoglobulins, thus supporting the suggestion that circulating antibody does not play an obligatory role in the process.
发现妊娠77天后任何时间移植的原位皮肤同种异体移植物会被胎羊排斥。在此之前，移植物保持原位，未引发任何可检测到的免疫反应。一旦胎儿获得排斥移植物的能力，这个过程就会以与成年动物相同的能力和速度发生。胎羊的移植物排斥反应不伴有浆细胞的形成或典型免疫球蛋白的产生，因此支持了循环抗体在该过程中不发挥强制性作用的观点。
