a Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation , Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico , Milan , Italy.
b Unit of General Pediatrics and Pediatric Infectious Diseases , IRCCS Bambino Gesù Hospital , Rome , Italy.
Expert Rev Anti Infect Ther. 2016;14(3):353-8. doi: 10.1586/14787210.2016.1136787. Epub 2016 Feb 3.
The Italian Society for Pediatric Infectious Diseases created a registry on children with infective endocarditis (IE) hospitalized in Italy.
A cross-sectional survey was conducted on patients hospitalized due to IE in Italian paediatric wards between January 1, 2000, and June 30, 2015.
Over the 15-year study period, 47 IE episodes were observed (19 males; age range, 2-17 years). Viridans Streptococci were the most common pathogens among patients with predisposing cardiac conditions and Staphylococcus aureus among those without (37.9% vs. 5.5%, p = 0.018, and 6.9% vs. 27.8%, p = 0.089, respectively). Six of the 7 (85.7%) S. aureus strains were methicillin-resistant. The majority of patients with and without predisposing cardiac conditions recovered without any complications.
In Italy, paediatric IE develops without any previous predisposing factors in a number of children, methicillin-resistant S. aureus has emerged as a common causative agent and the therapeutic approach is extremely variable.
意大利儿科传染病学会创建了一个意大利住院感染性心内膜炎（IE）患儿的登记处。
对 2000 年 1 月 1 日至 2015 年 6 月 30 日期间因 IE 住院的意大利儿科病房患者进行了横断面调查。
在 15 年的研究期间，观察到 47 例 IE 发作（19 名男性；年龄范围为 2-17 岁）。在有潜在心脏疾病的患者中，草绿色链球菌是最常见的病原体，而在无潜在心脏疾病的患者中，金黄色葡萄球菌是最常见的病原体（37.9%比 5.5%，p=0.018，6.9%比 27.8%，p=0.089）。7 株金黄色葡萄球菌中，有 6 株为耐甲氧西林金黄色葡萄球菌。有和无潜在心脏疾病的患者多数均无并发症康复。
在意大利，许多儿童的感染性心内膜炎没有任何先前的诱发因素，耐甲氧西林金黄色葡萄球菌已成为常见的病原体，治疗方法也极不统一。
