Briata Paola, Bordo Domenico, Puppo Margherita, Gorlero Franco, Rossi Martina, Perrone-Bizzozero Nora, Gherzi Roberto
Gene Expression Regulation Laboratory, IRCCS AOU San Martino-IST, Genova, Italy.
S.C. Ginecologia e Ostetricia Galliera Hospital, Genova, Italy.
Wiley Interdiscip Rev RNA. 2016 Mar-Apr;7(2):227-40. doi: 10.1002/wrna.1327. Epub 2015 Dec 27.
The single-stranded nucleic acid-binding protein KHSRP (KH-type splicing regulatory protein) modulates RNA life and gene expression at various levels. KHSRP controls important cellular functions as different as proliferation, differentiation, metabolism, and response to infectious agents. We summarize and discuss experimental evidence providing a potential link between changes in KHSRP expression/function and human diseases including neuromuscular disorders, obesity, type II diabetes, and cancer.
单链核酸结合蛋白KHSRP(KH型剪接调节蛋白)在多个层面调节RNA的生命历程和基因表达。KHSRP控制着诸如增殖、分化、代谢以及对感染因子的反应等不同的重要细胞功能。我们总结并讨论了相关实验证据,这些证据揭示了KHSRP表达/功能的变化与包括神经肌肉疾病、肥胖症、II型糖尿病和癌症在内的人类疾病之间的潜在联系。