metR基因产物和同型半胱氨酸对大肠杆菌glyA基因的调控
Regulation of the Escherichia coli glyA gene by the metR gene product and homocysteine.
作者信息
Plamann M D, Stauffer G V
机构信息
Department of Microbiology, University of Iowa, Iowa City 52242.
出版信息
J Bacteriol. 1989 Sep;171(9):4958-62. doi: 10.1128/jb.171.9.4958-4962.1989.
Abstract
The methionine component of glyA gene regulation in Escherichia coli K-12 was investigated. The results indicate that the glyA gene is positively controlled by the metR gene product. Activation of glyA by the MetR protein requires homocysteine, an intermediate in methionine biosynthesis. The positive-acting metR regulatory system functions independently of a regulatory system shown previously to control glyA gene expression.
摘要
对大肠杆菌K-12中glyA基因调控的甲硫氨酸成分进行了研究。结果表明，glyA基因受metR基因产物的正向调控。MetR蛋白对glyA的激活需要同型半胱氨酸，它是甲硫氨酸生物合成的中间产物。起正向作用的metR调控系统独立于先前显示的控制glyA基因表达的调控系统发挥作用。
相似文献
1
Regulation of the Escherichia coli glyA gene by the metR gene product and homocysteine.metR基因产物和同型半胱氨酸对大肠杆菌glyA基因的调控
J Bacteriol. 1989 Sep;171(9):4958-62. doi: 10.1128/jb.171.9.4958-4962.1989.
2
Characterization of the MetR binding sites for the glyA gene of Escherichia coli.大肠杆菌glyA基因的MetR结合位点的表征
J Bacteriol. 1995 Jul;177(14):4113-20. doi: 10.1128/jb.177.14.4113-4120.1995.
3
MetR-mediated repression of the glyA gene in Escherichia coli.
FEMS Microbiol Lett. 1996 Nov 1;144(2-3):229-33. doi: 10.1111/j.1574-6968.1996.tb08535.x.
4
Regulation of the Escherichia coli glyA gene by the purR gene product.purR基因产物对大肠杆菌glyA基因的调控
J Bacteriol. 1990 Jul;172(7):3799-803. doi: 10.1128/jb.172.7.3799-3803.1990.
5
Characterization of the Escherichia coli gene for serine hydroxymethyltransferase.大肠杆菌丝氨酸羟甲基转移酶基因的特性分析。
Gene. 1983 Apr;22(1):9-18. doi: 10.1016/0378-1119(83)90059-8.
6
A novel mechanism for upregulation of the Escherichia coli K-12 hmp (flavohaemoglobin) gene by the 'NO releaser', S-nitrosoglutathione: nitrosation of homocysteine and modulation of MetR binding to the glyA-hmp intergenic region.“一氧化氮释放剂”S-亚硝基谷胱甘肽上调大肠杆菌K-12 hmp（黄素血红蛋白）基因的新机制：同型半胱氨酸的亚硝化作用以及MetR与glyA-hmp基因间区域结合的调节
Mol Microbiol. 1998 Aug;29(4):1101-12. doi: 10.1046/j.1365-2958.1998.01000.x.
7
Cloning and characterization of the gene for Salmonella typhimurium serine hydroxymethyltransferase.鼠伤寒沙门氏菌丝氨酸羟甲基转移酶基因的克隆与特性分析
Gene. 1984 Jan;27(1):47-54. doi: 10.1016/0378-1119(84)90237-3.
8
Regulation of the metR gene of Salmonella typhimurium.鼠伤寒沙门氏菌metR基因的调控
J Bacteriol. 1987 Dec;169(12):5841-4. doi: 10.1128/jb.169.12.5841-5844.1987.
9
Role of homocysteine in metR-mediated activation of the metE and metH genes in Salmonella typhimurium and Escherichia coli.同型半胱氨酸在鼠伤寒沙门氏菌和大肠杆菌中metR介导的metE和metH基因激活中的作用。
J Bacteriol. 1989 Jun;171(6):3277-81. doi: 10.1128/jb.171.6.3277-3281.1989.
10
Cooperative MetR binding in the Escherichia coli glyA control region.
FEMS Microbiol Lett. 1996 Apr 1;137(2-3):147-52. doi: 10.1111/j.1574-6968.1996.tb08097.x.
引用本文的文献
1
Perturbation of the MetJ regulon impacts the consequences of 2-aminoacrylate stress in .MetJ调节子的扰动影响了2-氨基丙烯酸酯胁迫在……中的后果。 （你提供的原文句子不完整，缺少具体受影响的对象）
Microbiology (Reading). 2025 Jun;171(6). doi: 10.1099/mic.0.001572.
2
Quorum sensing in Vibrio controls carbon metabolism to optimize growth in changing environmental conditions.群体感应控制弧菌的碳代谢以优化在不断变化的环境条件下的生长。
PLoS Biol. 2024 Nov 11;22(11):e3002891. doi: 10.1371/journal.pbio.3002891. eCollection 2024 Nov.
3
A Cell-Free Biosensor for Assessment of Hyperhomocysteinemia.无细胞生物传感器用于评估高同型半胱氨酸血症。
ACS Synth Biol. 2023 Aug 18;12(8):2487-2492. doi: 10.1021/acssynbio.3c00103. Epub 2023 Jul 17.
4
Engineering of Biosynthesis Pathway and NADPH Supply for Improved L-5-Methyltetrahydrofolate Production by .用于改善.生产L-5-甲基四氢叶酸的生物合成途径和NADPH供应工程
J Microbiol Biotechnol. 2019 Jan 28;31(1):154-162. doi: 10.4014/jmb.1910.10069.
5
The In Vitro Redundant Enzymes PurN and PurT Are Both Essential for Systemic Infection of Mice in Salmonella enterica Serovar Typhimurium.鼠伤寒沙门氏菌中体外冗余酶PurN和PurT对小鼠全身感染均至关重要。
Infect Immun. 2016 Jun 23;84(7):2076-2085. doi: 10.1128/IAI.00182-16. Print 2016 Jul.
6
Electrochemical selection and characterization of a high current-generating Shewanella oneidensis mutant with altered cell-surface morphology and biofilm-related gene expression.具有改变的细胞表面形态和生物膜相关基因表达的高电流产生型嗜铁还原地杆菌突变体的电化学筛选与表征
BMC Microbiol. 2014 Jul 16;14:190. doi: 10.1186/1471-2180-14-190.
7
MetR-regulated Vibrio cholerae metabolism is required for virulence.代谢调控的霍乱弧菌代谢对于毒力是必需的。
mBio. 2012 Sep 25;3(5). doi: 10.1128/mBio.00236-12. Print 2012.
8
Structure of the regulatory domain of the LysR family regulator NMB2055 (MetR-like protein) from Neisseria meningitidis.来自脑膜炎奈瑟菌的LysR家族调节因子NMB2055（类MetR蛋白）调节结构域的结构
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jul 1;68(Pt 7):730-7. doi: 10.1107/S1744309112010603. Epub 2012 Jun 22.
9
The Streptococcus iniae transcriptional regulator CpsY is required for protection from neutrophil-mediated killing and proper growth in vitro.副猪嗜血杆菌转录调控因子 CpsY 有助于抵抗中性粒细胞介导的杀伤并在体外实现正常生长。
Infect Immun. 2011 Nov;79(11):4638-48. doi: 10.1128/IAI.05567-11. Epub 2011 Sep 12.
10
Swarming of Pseudomonas aeruginosa is controlled by a broad spectrum of transcriptional regulators, including MetR.铜绿假单胞菌的群体游动受包括MetR在内的多种转录调节因子控制。
J Bacteriol. 2009 Sep;191(18):5592-602. doi: 10.1128/JB.00157-09. Epub 2009 Jul 10.
本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
GLYCINE SYNTHESIS AND METABOLISM IN ESCHERICHIA COLI.大肠杆菌中的甘氨酸合成与代谢
J Bacteriol. 1965 Apr;89(4):1145-50. doi: 10.1128/jb.89.4.1145-1150.1965.
3
Intermediatry metabolism of Diplococcus glycinophilus. I. Glycine cleavage and one-carbon interconversions.甘氨酸嗜双球菌的中间代谢。I. 甘氨酸裂解和一碳相互转化。
J Bacteriol. 1961 Apr;81(4):541-9. doi: 10.1128/jb.81.4.541-549.1961.
4
Construction and expression of hybrid plasmids containing the Escherichia coli glyA genes.含有大肠杆菌glyA基因的杂交质粒的构建与表达。
Gene. 1981 Jun-Jul;14(1-2):63-72. doi: 10.1016/0378-1119(81)90148-7.
5
Role of methionine in the regulation of the synthesis of serine hydroxymethyltransferase in Escherichia coli.甲硫氨酸在大肠杆菌中对丝氨酸羟甲基转移酶合成的调控作用。
J Biol Chem. 1984 Jul 10;259(13):8402-6.
6
Regulation of synthesis of serine hydroxymethyltransferase in chemostat cultures of Escherichia coli.大肠杆菌恒化器培养物中丝氨酸羟甲基转移酶合成的调控
J Biol Chem. 1984 Jul 10;259(13):8394-401.
7
Escherichia coli K12 mutants defective in the glycine cleavage enzyme system.在甘氨酸裂解酶系统中存在缺陷的大肠杆菌K12突变体。
Mol Gen Genet. 1983;192(1-2):15-20. doi: 10.1007/BF00327641.
8
Dominance of the wild-type alleles of methionine regulatory genes in Salmonella typhimurium.
J Gen Microbiol. 1970 Sep;63(1):95-109. doi: 10.1099/00221287-63-1-95.
9
Chain initiation in a polycistronic message: sequential versus simultaneous derepression of the enzymes for histidine biosynthesis in Salmonella typhimurium.多顺反子信息中的链起始：鼠伤寒沙门氏菌中组氨酸生物合成酶的顺序去阻遏与同时去阻遏
Proc Natl Acad Sci U S A. 1967 Jun;57(6):1857-64. doi: 10.1073/pnas.57.6.1857.
10
Regulation of one-carbon biosynthesis and utilization in Escherichia coli.大肠杆菌中一碳生物合成与利用的调控
J Bacteriol. 1974 Jun;118(3):905-10. doi: 10.1128/jb.118.3.905-910.1974.
Zotero 插件