Rades Dirk, Schild Steven E, Bajrovic Amira, Janssen Stefan, Bartscht Tobias
Department of Radiation Oncology, University of Lübeck, Lübeck, Germany
Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ, U.S.A.
In Vivo. 2016 Jan-Feb;30(1):69-72.
To facilitate personalization of radiotherapy (RT) for elderly patients with epidural cord compression (ECC) from gastric cancer.
Several factors were analyzed for survival in 20 elderly patients including age, gender, time period from gastric cancer diagnosis to ECC, metastatic spread, additional osseous lesions, vertebral bodies afflicted by ECC, ambulatory function, dynamic of motor dysfunction, performance status and RT fractionation.
Four factors had a significant influence on survival: metastatic spread (p<0.001), ambulatory function (p=0.001), dynamics of motor dysfunction (p=0.002) and performance status (p=0.003). Points were assigned according to factors present for each patient. To avoid confounding variables, performance status was not incorporated into the scoring system. Based on 3-month survival rates, patients were divided into four groups according to the total score: 6, 12-13, 19 and 26 points. Three-month survival rates for these groups were 0%, 50%, 75% and 100%, respectively (p<0.001).
This score is of great assistance when assigning the appropriate RT approach to an elderly patient with ECC from gastric cancer.
促进对老年胃癌硬膜外脊髓压迫（ECC）患者放疗（RT）的个体化。
分析了20例老年患者的多个生存相关因素，包括年龄、性别、从胃癌诊断到ECC的时间、转移扩散、额外的骨病变、受ECC影响的椎体、行走功能、运动功能障碍的动态变化、体能状态和放疗分割。
四个因素对生存有显著影响：转移扩散（p<0.001）、行走功能（p=0.001）、运动功能障碍的动态变化（p=0.002）和体能状态（p=0.003）。根据每位患者存在的因素进行评分。为避免混杂变量，体能状态未纳入评分系统。根据3个月生存率，患者按总分分为四组：6分、12 - 13分、19分和26分。这些组的3个月生存率分别为0%、50%、75%和100%（p<0.001）。
该评分在为老年胃癌ECC患者确定合适的放疗方法时非常有帮助。
