Shukla Vaibhav, Dey Rahul, Chandra Ashok, Karoli Ritu, Khanduri Sachin
J Assoc Physicians India. 2015 Jun;63(6):30-3.
The last few years have seen a phenomenal increase in the prevalence of chronic kidney disease (CKD). Cardiovascular disease remains the most important cause of death in these patients.The present study was conducted to evaluate endothelial dysfunction in CKD patients as compared with controls.
Thirty-five patients of CKD and 32 age and sex-matched controls were included in the study. Flow-mediated vasodilatation was assessed in all individuals. Anthropometric measurements, haematological and biochemical assessment were also done.
It was found that patients of CKD had significant endothelial dysfunction in comparison with controls as assessed by flow-mediated vasodilatation of brachial artery. It was also seen that late stages of CKD patients had significant endothelial dysfunction in comparison to early stages of CKD.
The present study concludes that chronic kidney disease patients have significant endothelial dysfunction and this is more pronounced in the later stages of the disease.
在过去几年中，慢性肾脏病（CKD）的患病率显著上升。心血管疾病仍然是这些患者最重要的死因。本研究旨在评估CKD患者与对照组相比的内皮功能障碍情况。
本研究纳入了35例CKD患者以及32例年龄和性别匹配的对照组。对所有个体进行了血流介导的血管舒张功能评估。还进行了人体测量、血液学和生化评估。
通过肱动脉血流介导的血管舒张功能评估发现，与对照组相比，CKD患者存在显著的内皮功能障碍。还发现，与CKD早期相比，CKD晚期患者存在显著的内皮功能障碍。
本研究得出结论，慢性肾脏病患者存在显著的内皮功能障碍，且在疾病后期更为明显。
