Wang Fucai, Xie Yong
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2015 Aug;32(4):919-23.
High mobility group box 1 protein (HMGB1), a damage-associated molecular pattern, exists ubiquitously in the cells of mammals. It contributes to maintaining the structure of nucleosome and modulating transcription of gene in nuclei. Extracellular HMGB1 plays two-way roles in promoting inflammatory and tissue repair. Released actively as well as passively following cytokine stimulation during cell death, HMGB1 may act as a late inflammatory factor and an endogenous damage-associated molecular pattern recognized by its receptors. And it may mediate the occurrence, development and outcome of the inflammatory injury of digestive system diseases, such as gastric mucosal injury, inflammatory bowel-disease, liver injury, pancreatitis, and so on. This review mainly concerns the research progresses of HMGB1 in the inflammatory injury of digestive system diseases. At the same time, HMGB1 itself, or as a therapeutic target, can promote tissue repair.
高迁移率族蛋白B1（HMGB1）是一种损伤相关分子模式，普遍存在于哺乳动物细胞中。它有助于维持核小体结构并调节细胞核内基因的转录。细胞外HMGB1在促进炎症和组织修复方面发挥双向作用。在细胞死亡期间，HMGB1在细胞因子刺激后主动或被动释放，它可能作为晚期炎症因子和一种被其受体识别的内源性损伤相关分子模式。并且它可能介导消化系统疾病炎症损伤的发生、发展和转归，如胃黏膜损伤、炎症性肠病、肝损伤、胰腺炎等。本文综述主要关注HMGB1在消化系统疾病炎症损伤方面的研究进展。同时，HMGB1本身或作为治疗靶点可促进组织修复。
