Belkacemi Louiza, Belalia Mahmoud
Laboratoire de technologie alimentaire et nutrition, Université Abd ElHamid Ibn Badis, Mostaganem, Algeria.
Laboratoire de structure, Élaboration et application des matériaux moléculaires, Université Abd ElHamid Ibn Badis, Mostaganem, Algeria.
Diabetes Metab Syndr. 2016 Jan-Mar;10(1 Suppl 1):S147-50. doi: 10.1016/j.dsx.2015.10.013. Epub 2015 Nov 12.
The magnitude of abnormal liver enzymes profile in type 2 diabetic patients is unknown in Algerian west region even though it counts among liver diseases considered as an important cause of death in type 2 diabetes. The main objective is to assess the prevalence of elevated liver enzymes levels among patients with type 2 diabetes from Algerian west region and to determine associated risk factors.
A descriptive cross sectional study was performed on 180 type 2 diabetic patients in whom anthropometric and biochemical parameters were determined.
Twenty-five patients had abnormal elevated alanine transaminase (ALT) (13.9%) with the gender-wise prevalence being 15.9% (n=17) in women and 10.9% (n=8) in men. The prevalence of abnormal elevated aspartate transaminase (AST), gamma glutamyl transferase and alkaline phosphatase level was respectively 10% (n=18), 6.1% (n=11) and 8.9% (16). High waist circumference (OR: 5, CI: 1.04-24.04) and high blood pressure (OR: 4.86, CI: 0.94-25.12) were only associated with elevated AST. Fasting glucose >1.4g/l were associated both with elevated ALT (OR: 3.03, CI: 0.86-10.67) and AST (OR: 5.7, CI: 1.09-29.8).
A relatively high prevalence of elevated liver enzymes was found in diabetic patients from west Algeria, especially in female patients.
尽管在2型糖尿病中，肝脏疾病被认为是重要的死亡原因之一，但阿尔及利亚西部地区2型糖尿病患者肝酶谱异常的程度尚不清楚。主要目的是评估阿尔及利亚西部地区2型糖尿病患者肝酶水平升高的患病率，并确定相关危险因素。
对180例2型糖尿病患者进行了描述性横断面研究，测定了人体测量和生化参数。
25例患者丙氨酸转氨酶（ALT）异常升高（13.9%），按性别患病率分别为女性15.9%（n = 17），男性10.9%（n = 8）。天冬氨酸转氨酶（AST）、γ-谷氨酰转移酶和碱性磷酸酶水平异常升高的患病率分别为10%（n = 18）、6.1%（n = 11）和8.9%（n = 16）。高腰围（OR：5，CI：1.04 - 24.04）和高血压（OR：4.86，CI：0.94 - 25.12）仅与AST升高有关。空腹血糖>1.4g/l与ALT升高（OR：3.03，CI：0.86 - 10.67）和AST升高（OR：5.7，CI：1.09 - 29.8）均有关。
在阿尔及利亚西部的糖尿病患者中发现肝酶升高的患病率相对较高，尤其是女性患者。
