Master's Program in Science and Health, Federal University of Piauí, Brazil.
Hum Immunol. 2013 Dec;74(12):1598-602. doi: 10.1016/j.humimm.2013.08.283. Epub 2013 Aug 29.
This study aimed to report the antigen and haplotype frequencies (HFs) of volunteer bone marrow donors (VBMDs) from the state of Piauí who were enrolled in the National Volunteer Bone Marrow Donor Registry (REDOME). The research subjects were 21,943 volunteer bone marrow donors, predominantly young adult women (53.3%). The most frequent allelic group was HLA-A2, followed by -DRB113, -DRB104, -DRB107, -B15, -B∗35, -B44, -A24 and -A03. Of the 2,704 haplotypes observed, the three most frequent haplotypes were A29 B44 DRB107 (1.45%), A01 B08 DRB103 (1.4%) and A03 B07 DRB115 (0.92%). These three haplotypes were in linkage disequilibrium. PCA showed that 98% of the VBMDs have HLA allele frequencies that are very similar to those from Teresina, the capital city of Piauí. According to the PCA results, these municipalities are distributed with a close proximity to Teresina, which in turn has a close genetic proximity to the Hispanic ethnicity, intermediate proximity to Caucasians and Africans and a distant kinship to Amerindians. The hierarchical proximity of the population of Piauí to the Portuguese and Hispanic populations to shows the strong influence of the latter on the former.
本研究旨在报告来自皮奥伊州的志愿者骨髓捐献者（VBMD）的抗原和单倍型频率（HFs），这些捐献者已被纳入国家志愿者骨髓捐献者登记处（REDOME）。研究对象为 21943 名志愿者骨髓捐献者，主要是年轻成年女性（53.3%）。最常见的等位基因群是 HLA-A2，其次是-DRB113、-DRB104、-DRB107、-B15、-B∗35、-B44、-A24 和 -A03。在所观察到的 2704 个单倍型中，最常见的三个单倍型是 A29 B44 DRB107（1.45%）、A01 B08 DRB103（1.4%）和 A03 B07 DRB115（0.92%）。这三个单倍型处于连锁不平衡状态。PCA 显示，98%的 VBMD 具有与皮奥伊州首府特雷斯皮纳斯非常相似的 HLA 等位基因频率。根据 PCA 结果，这些城市与特雷斯皮纳斯的分布非常接近，而特雷斯皮纳斯与西班牙裔人群具有密切的遗传关系，与白种人和非洲人关系较近，与美洲印第安人关系较远。皮奥伊州人口与葡萄牙和西班牙裔人群的分层接近表明，后者对前者有很强的影响。
