Moreno Monica A, Burns Travis, Yao Pamela, Miers Laird, Pleasure David, Soulika Athena M
Shriners Hospital for Children, Northern California, Sacramento, CA, USA; University of California, Davis, School of Medicine, Sacramento, CA, USA.
Shriners Hospital for Children, Northern California, Sacramento, CA, USA.
J Neuroimmunol. 2016 Jan 15;290:36-46. doi: 10.1016/j.jneuroim.2015.11.004. Epub 2015 Nov 10.
Studies in multiple sclerosis and its animal model experimental autoimmune encephalomyelitis (EAE) suggest that peripheral monocyte-derived cells (MDCs) are instrumental for disease initiation. MDCs, however, are plastic, and may exert various functions once in the central nervous system (CNS) for prolonged periods. Furthermore, the long-term effect of MDC depletion on continuing axon loss is not known. We show that long-lasting depletion of MDCs, after onset of EAE clinical deficits, is accompanied by decreased CNS infiltration by pathogenic T lymphocytes. Although this treatment does not reverse clinical disease, it prevents worsening of neurological deficits and long-term axonal loss.
对多发性硬化症及其动物模型实验性自身免疫性脑脊髓炎（EAE）的研究表明，外周血单核细胞衍生细胞（MDCs）对疾病的起始起重要作用。然而，MDCs具有可塑性，一旦长期存在于中枢神经系统（CNS）中，可能发挥多种功能。此外，MDCs耗竭对持续性轴突损失的长期影响尚不清楚。我们发现，在EAE临床症状出现后，MDCs的长期耗竭伴随着致病性T淋巴细胞对CNS浸润的减少。虽然这种治疗不能逆转临床疾病，但它可防止神经功能缺损的恶化和长期轴突损失。
