Weijers Gerrit, Wanten Geert, Thijssen Johan M, van der Graaf Marinette, de Korte Chris L
Medical Ultrasound Imaging Centre (MUSIC), Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands.
Ultrasound Med Biol. 2016 Mar;42(3):637-44. doi: 10.1016/j.ultrasmedbio.2015.11.004. Epub 2015 Dec 19.
Patients on home parenteral nutrition are at risk for developing liver dysfunction, which is due partly to the accumulation of lipids in the liver (steatosis) and may progress to end-stage liver disease with overt liver failure. Therefore, a timely diagnosis with easy access to repeated assessment of the degree of liver steatosis is of great importance. A pilot study was performed in 14 patients on long-term home parenteral nutrition using the computer-aided ultrasound method. Ultrasound radio frequency data were acquired using a phased array transducer and were converted into conventional B-mode images. All patients were subjected to proton magnetic resonance spectroscopy measurement of liver fat content for reference. Computer-aided ultrasound parameters similar to those in a previous validation study in cows revealed significant correlations with fat content measured by magnetic resonance spectroscopy. The most significant parameters were the residual attenuation coefficient (R = 0.95, p < 0.001) and the lateral speckle size (R = 0.77, p = 0.021). These findings indicate the potential usefulness of computer-aided ultrasound for staging of hepatic steatosis.
接受家庭肠外营养的患者有发生肝功能障碍的风险，这部分归因于肝脏中脂质的积累（脂肪变性），并且可能进展为伴有明显肝衰竭的终末期肝病。因此，及时诊断并能够方便地反复评估肝脏脂肪变性程度非常重要。使用计算机辅助超声方法对14例接受长期家庭肠外营养的患者进行了一项初步研究。使用相控阵换能器采集超声射频数据，并将其转换为传统的B模式图像。所有患者均接受质子磁共振波谱测量肝脏脂肪含量以供参考。与之前在奶牛身上进行的验证研究中相似的计算机辅助超声参数显示，与通过磁共振波谱测量的脂肪含量存在显著相关性。最显著的参数是残余衰减系数（R = 0.95，p < 0.001）和横向散斑大小（R = 0.77，p = 0.021）。这些发现表明计算机辅助超声在肝脂肪变性分期方面具有潜在的应用价值。
