微小RNA（miRNA）通路中的RNA结合蛋白
RNA Binding Proteins in the miRNA Pathway.
作者信息
Connerty Patrick, Ahadi Alireza, Hutvagner Gyorgy
机构信息
Faculty of Science 1, University of Technology, Sydney, NSW 2007, Australia.
Faculty of Engineering and Information technology 2, University of Technology, Sydney, NSW 2007, Australia.
出版信息
Int J Mol Sci. 2015 Dec 26;17(1):31. doi: 10.3390/ijms17010031.
microRNAs (miRNAs) are short ~22 nucleotides (nt) ribonucleic acids which post-transcriptionally regulate gene expression. miRNAs are key regulators of all cellular processes, and the correct expression of miRNAs in an organism is crucial for proper development and cellular function. As a result, the miRNA biogenesis pathway is highly regulated. In this review, we outline the basic steps of miRNA biogenesis and miRNA mediated gene regulation focusing on the role of RNA binding proteins (RBPs). We also describe multiple mechanisms that regulate the canonical miRNA pathway, which depends on a wide range of RBPs. Moreover, we hypothesise that the interaction between miRNA regulation and RBPs is potentially more widespread based on the analysis of available high-throughput datasets.
微小RNA（miRNA）是约22个核苷酸（nt）的短核糖核酸，可在转录后调节基因表达。miRNA是所有细胞过程的关键调节因子，其在生物体中的正确表达对于正常发育和细胞功能至关重要。因此，miRNA生物合成途径受到高度调控。在本综述中，我们概述了miRNA生物合成和miRNA介导的基因调控的基本步骤，重点关注RNA结合蛋白（RBP）的作用。我们还描述了多种调节经典miRNA途径的机制，该途径依赖于多种RBP。此外，基于对现有高通量数据集的分析，我们推测miRNA调控与RBP之间的相互作用可能更为广泛。
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