探索丙戊酸自闭症动物模型的有效性。
Exploring the Validity of Valproic Acid Animal Model of Autism.
作者信息
Mabunga Darine Froy N, Gonzales Edson Luck T, Kim Ji-Woon, Kim Ki Chan, Shin Chan Young
机构信息
Department of Neuroscience, School of Medicine, and Neuroscience Research Center, SMART-IABS and KU Open Innovation Center, Konkuk University, Seoul 05029, Korea.
Department of Neuroscience, School of Medicine, and Neuroscience Research Center, SMART-IABS and KU Open Innovation Center, Konkuk University, Seoul 05029, Korea. ; Department of Pharmacology, School of Medicine, Konkuk University, Seoul 05029, Korea.
出版信息
Exp Neurobiol. 2015 Dec;24(4):285-300. doi: 10.5607/en.2015.24.4.285. Epub 2015 Dec 16.
The valproic acid (VPA) animal model of autism spectrum disorder (ASD) is one of the most widely used animal model in the field. Like any other disease models, it can't model the totality of the features seen in autism. Then, is it valid to model autism? This model demonstrates many of the structural and behavioral features that can be observed in individuals with autism. These similarities enable the model to define relevant pathways of developmental dysregulation resulting from environmental manipulation. The uncovering of these complex pathways resulted to the growing pool of potential therapeutic candidates addressing the core symptoms of ASD. Here, we summarize the validity points of VPA that may or may not qualify it as a valid animal model of ASD.
丙戊酸（VPA）诱导的自闭症谱系障碍（ASD）动物模型是该领域使用最广泛的动物模型之一。与其他任何疾病模型一样，它无法模拟出自闭症患者所具有的全部特征。那么，用它来模拟自闭症是否有效呢？该模型展现出了许多可在自闭症患者身上观察到的结构和行为特征。这些相似之处使该模型能够确定因环境干预导致的发育失调的相关途径。对这些复杂途径的揭示，催生了越来越多针对ASD核心症状的潜在治疗候选药物。在此，我们总结了丙戊酸作为ASD有效动物模型可能具备或不具备的有效性要点。
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